一項研究發(fā)現(xiàn),，本地的熊蜂為了覓食而長距離地尋找物種豐富的花叢,，而且提示這些蜂的覓食距離取決于花叢的多樣性而非密度,。Shalene Jha 和Claire Kremen使用一種種群遺傳學方法研究了Bombus vosnesenskii這種熊蜂的覓食模式，這是一種瀕危的本地授粉者。這組作者對加州8個研究區(qū)域的工蜂進行了取樣,，并根據(jù)它們的DNA的13個微衛(wèi)星位點確定了這些個體所屬的蜂群,。然后這組作者根據(jù)Bombus vosnesenskii在一個地理區(qū)域的姐妹配對的相對頻率并且通過計算所有的姐妹配對相互距離多遠以及與中心蜂群的假定位置的距離從而估計了這些蜂的最大覓食距離。在被研究的地區(qū),，對這些蜂的最大覓食距離的估計從82米到2783米不等,，蜂群同伴的平均覓食距離從13米到600米之間，這表明覓食距離比此前認為的差異要大很多,。在花叢與花叢之間相對同質(zhì)的花覆蓋區(qū)域,，蜂為了覓食而遠距離地尋找物種豐富性大的花叢。這組作者說,，這些結(jié)果可能用于指導自然地形和人類改變的地形的管理,，從而增加本地蜂筑巢和長距離覓食。(生物谷Bioon.com)
doi:10.1038/ng.2505
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Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer
Wei-Hua Jia,1, 16 Ben Zhang,2, 16 Keitaro Matsuo,3 Aesun Shin,4 Yong-Bing Xiang,5 Sun Ha Jee,6 Dong-Hyun Kim,7 Zefang Ren,1 Qiuyin Cai,2 Jirong Long,2 Jiajun Shi,2 Wanqing Wen,2 Gong Yang,2 Ryan J Delahanty,2 Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Colon Cancer Family Registry (CCFR), Bu-Tian Ji,9 Zhi-Zhong Pan,1 Fumihiko Matsuda,10 Yu-Tang Gao,5 Jae Hwan Oh,11 Yoon-Ok Ahn,12 Eun Jung Park,6 Hong-Lan Li,5 Ji Won Park,11 Jaeseong Jo,6 Jin-Young Jeong,7 Satoyo Hosono,3 Graham Casey,13 Ulrike Peters,14, 15 Xiao-Ou Shu,2 Yi-Xin Zeng1, 17 & Wei Zheng2, 17
To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, including up to 5,358 cases and 5,922 controls. We identified four SNPs with association P values of 8.58 × 10−7 to 3.77 × 10−10 in the combined analysis of all east Asian samples. Three of the four were replicated in a study conducted in 26,060 individuals of European descent, with combined P values of 1.22 × 10−10 for rs647161 (5q31.1), 6.64 × 10−9 for rs2423279 (20p12.3) and 3.06 × 10−8 for rs10774214 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both east Asian and European-ancestry populations. This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC.
