關(guān)于沉默性中風(fēng)或死亡腦細胞小斑點的新研究發(fā)現(xiàn)大約有1/4的老年人記憶喪失,。這項研究發(fā)表在2012年1月3日印刷發(fā)行的美國神經(jīng)學(xué)會醫(yī)學(xué)雜志?《神經(jīng)病學(xué)》上,。
來自紐約哥倫比亞大學(xué)醫(yī)學(xué)中心Taub 阿爾茨海默氏癥與老化腦部研究所（Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center）的該研究的作者Adam M. Brickman博士說："這項老年人記憶喪失研究的新內(nèi)容是同時考察沉默性中風(fēng)和海馬萎縮",。
在此研究中，一組年齡65歲以上,、無癡呆的老人,，共658人，進行了大腦核磁共振掃描,。參與者還接受了相關(guān)測試,，這些測試測量他們的記憶，語言,，視覺感知和信息處理速度,。其中共有174人有沉默性中風(fēng)。
研究發(fā)現(xiàn),，與無沉默性中風(fēng)的人相比,，沉默性中風(fēng)的人在記憶測試中得分更糟糕。人是否有一個小海馬是真正的,，這里的海馬是大腦的記憶中心,。
"如果如阿爾茨海默氏病這種情況主要是由記憶問題所確定，我們的結(jié)果可能導(dǎo)致進一步深入了解癥狀引發(fā)原因和新預(yù)防干預(yù)的開發(fā),。在我們的研究中,，既然沉默性中風(fēng)和海馬體積分別與記憶喪失相關(guān)，我們的研究結(jié)果也支持預(yù)防中風(fēng)作為避免記憶問題的一種手段",，Brickman說,。
該研究由NIH資助。（生物谷bioon.com）
doi:10.1212/WNL.0b013e31823e
PMC:
PMID:
Memory after silent stroke: Hippocampus and infarcts both matter
S. Blum, J.A. Luchsinger, J.J. Manly, N. Schupf, Y. Stern, T.R. Brown, C. DeCarli, S.A. Small, R. Mayeux, and A.M. Brickman
Abstract Objective: Memory decline commonly occurs among elderly individuals. This observation is often attributed to early neurodegenerative changes in the hippocampus and related brain regions. However, the contribution of vascular lesions, such as brain infarcts, to hippocampal integrity and age-associated memory decline remains unclear. Methods: We studied 658 elderly participants without dementia from a prospective, community-based study on aging and dementia who received high-resolution structural MRI. Cortical and subcortical infarcts were identified, and hippocampal and relative brain volumes were calculated following standard protocols. Summary scores reflecting performance on tasks of memory, language, processing speed, and visuospatial function were derived from a comprehensive neuropsychological battery. We used multiple regression analyses to relate cortical and subcortical infarcts, hippocampal and relative brain volume, to measures of cognitive performance in domains of memory, language, processing speed, and visuospatial ability. Results: Presence of brain infarcts was associated with a smaller hippocampus. Smaller hippocampus volume was associated with poorer memory specifically. Brain infarcts were associated with poorer memory and cognitive performance in all other domains, which was independent of hippocampus volume. Conclusions: Both hippocampal volume and brain infarcts independently contribute to memory performance in elderly individuals without dementia. Given that age-associated neurodegenerative conditions, such as Alzheimer disease, are defined primarily by impairment in memory, these findings have clinical implications for prevention and for identification of pathogenic factors associated with disease symptomatology.
