體外堿性成纖維細胞生長因子能促進瘤壁平滑肌細胞增殖,，這可能有助于修復頸內(nèi)動脈瘤壁,?！吨袊窠?jīng)再生研究（英文版）》雜志于2012年12月36期出版的一項關于“Basic fibroblast growth factor gene transfection in repair of internal carotid artery aneurysm wall”的研究結果顯示：①攜帶堿性成纖維細胞生長因子的慢病毒可使動脈瘤瘤壁處于增殖期的血管平滑肌細胞增多，有促進血管壁平滑肌細胞增殖的作用,。②且能抑制動脈瘤的生長,，早期干預修復瘤壁的能力更強。(生物谷Bioon.com)

doi:10.3969/j.issn.1673-5374.2012.36.009
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Basic fibroblast growth factor gene transfection in repair of internal carotid artery aneurysm wall

Lei Jiao, Ming Jiang, Jinghai Fang, Yinsheng Deng, Zejun Chen, Min Wu

Surgery or interventional therapy has some risks in the treatment of cerebral aneurysm. We established an internal carotid artery aneurysm model by dripping elastase in the crotch of the right internal and external carotid arteries of New Zealand rabbits. Following model induction, lentivirus carrying basic fibroblast growth factor was injected through the ear vein. We found that the longer the action time of the lentivirus, the smaller the aneurysm volume. Moreover, platelet-derived growth factor expression in the aneurysm increased, but smooth muscle 22 alpha and hypertension-related gene 1 mRNA expression decreased. At 1, 2, 3, and 4 weeks following model establishment, following 1 week of injection of lentivirus carrying basic fibroblast growth factor, the later the intervention time, the more severe the blood vessel damage, and the bigger the aneurysm volume, the lower the smooth muscle 22 alpha and hypertension-related gene 1 mRNA expression. Simultaneously, platelet-derived growth factor expression decreased. These data suggest that recombinant lentivirus carrying basic fibroblast growth factor can repair damaged cells in the aneurysmal wall and inhibit aneurysm dynamic growth, and that the effect is dependent on therapeutic duration.