酮咯酸氨丁三醇對(duì)眼底疾病如脈絡(luò)膜新生血管，視網(wǎng)膜新生血管,，糖尿病視網(wǎng)膜眼底病變及黃斑囊樣水腫的治療有較大潛力,，但在給藥方式和劑量的應(yīng)用上有很多爭(zhēng)議?！吨袊?guó)神經(jīng)再生研究（英文版）》雜志于2012年12月35期出版的一項(xiàng)關(guān)于“Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage”的研究顯示,，給正常新西蘭大白兔右眼脈絡(luò)膜上腔注射3000，6000μg的酮咯酸氨丁三醇后,，其視網(wǎng)膜電圖波形,、振幅和潛伏期均未出現(xiàn)異常改變，兔視網(wǎng)膜神經(jīng)節(jié)細(xì)胞層,、內(nèi)網(wǎng)狀層、內(nèi)核層,、外核層和光感受器層細(xì)胞形態(tài)和排列未出現(xiàn)明顯變化,，視網(wǎng)膜形態(tài)結(jié)構(gòu)也未出現(xiàn)明顯變化。這項(xiàng)研究結(jié)果說(shuō)明,，劑量為3000,，6000μg的酮咯酸氨丁三醇在兔眼脈絡(luò)膜上腔單次注射是安全的，且給藥方式也是安全的,。(生物谷Bioon.com)
doi:10.3969/j.issn.1673-5374.2012.35.004
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PMID:
Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage
Sumeng Liu1, Wu Liu2, Yaling Ma1, Kegao Liu2, Meizi Wang2
Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1, 2, and 4 weeks after injection. There was no difference between left (control) and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe.
