脊神經(jīng)后根切斷后導致反射性陰莖勃起功能喪失，影響痙攣性膀胱患者的生活質量,。一項關于“Selective control by posterior spinal nerve roots of micturition and erection in rats ”的研究顯示,，SD大鼠L6、S1脊神經(jīng)后根不同神經(jīng)小束對膀胱逼尿肌,、尿道外括約肌和陰莖海綿體的傳導效能存在差別,，通過電刺激可以區(qū)別不同的神經(jīng)小束,。作者認為，高選擇切斷支配尿道外括約肌的骶前根小束可以解除括約肌痙攣,，從而達到低壓排尿及提高膀胱協(xié)調性的目的,；通過高選擇切斷傳導逼尿肌脊神經(jīng)后根可以緩解膀胱痙攣，達到擴大膀胱容量同時保留勃起功能的目的,。該研究可為臨床高選擇性脊神經(jīng)后根小束切斷治療痙攣性膀胱提供理論依據(jù),。相關研究成果發(fā)表在《中國神經(jīng)再生研究（英文版）》雜志于2012年12 月35 期出版的雜志上。(生物谷Bioon.com)
doi:10.3969/j.issn.1673-5374.2012.35.001
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Selective control by posterior spinal nerve roots of micturition and erection in rats
Wenting Wang, Mouwang Zhou, Genying Zhu, Tao Li, Nan Liu
The posterior rootlets in L6 and S1 spinal cord of adult male Sprague-Dawley rats underwent electrostimulation. The bladder pressure, urethral perfusion pressure and intracavernous pressure were recorded. When some posterior rootlets of L6 and S1 were electrostimulated, the intracavernous pressure peaked rapidly, but the bladder pressure and the urethral perfusion pressure curve did not show great change. When other rootlets were stimulated, the bladder pressure changed greatly, but the urethral perfusion pressure and the intracavernous pressure did not show great change. When different rootlets were stimulated, the urethral perfusion pressure changed maximally, but there were no great changes in bladder pressure or intracavernous pressure. Furthermore, stimulation of some rootlets produced simultaneous changes in two or three different pressure measures mentioned above. The results demonstrate that regulation by L6 and S1 posterior rootlets of the rat bladder detrusor, external urethral sphincter and penis cavernous body are significantly distinct. Different rootlets can be distinguished by electrostimulation.
