雌激素能夠抑制神經(jīng)細胞凋亡,，植物激素作為雌激素替代物也能產(chǎn)生類似作用，染料木素是一種異黃酮，結(jié)構(gòu)相似于17β-雌二醇，具有抗氧化性及對雌激素受體的高親和性,，是目前研究的主要植物雌激素?！吨袊窠?jīng)再生研究（英文版）》雜志于2012年12月36期出版的一項關于“Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats”的研究顯示,，去卵巢雌鼠進行連續(xù)15周腹腔注射染料木素，可通過上調(diào)Bcl-2的表達,，下調(diào)Bax的表達,，減少去卵巢大鼠海馬結(jié)構(gòu)內(nèi)神經(jīng)元凋亡，且效果與17β-雌二醇相當,。(生物谷Bioon.com)

doi:10.3969/j.issn.1673-5374.2012.36.004
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Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats

Yun Peng1, Bo Jiang1, Huiling Wu1, Ruchun Dai2, Liming Tan1

Genistein is one of several isoflavones that has a structure similar to 17β-estradiol, has a strong antioxidant effect, and a high affinity to estrogen receptors. At 15 weeks after ovariectomy, the expression of Bcl-2 in the hippocampus of rats decreased and Bax expression increased, with an obvious upregulation of apoptosis. However, intraperitoneal injection of genistein or 17β-estradiol for 15 consecutive weeks from the second day after operation upregulated Bcl-2 protein expression, downregulated Bax protein expression, and attenuated hippocampal neuron apoptosis. Our experimental findings indicate that long-term intervention with genistein can lead to a decrease in apoptosis in hippocampal neurons following ovariectomy, upregulate the expression of Bcl-2, and downregulate the expression of Bax. In addition, genistein and 17β-estradiol play equal anti-apoptotic and neuroprotective roles.