一項(xiàng)關(guān)于“Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats”的研究,，通過連續(xù)14 d皮下注射40 mg/kg糖皮質(zhì)激素建立成年SD大鼠慢性應(yīng)激模型，與此同時(shí)灌胃50 mg/kg的黃岑苷,，觀察其對(duì)慢性應(yīng)激大鼠神經(jīng)發(fā)生的影響,。
結(jié)果顯示皮下注射糖皮質(zhì)激素可顯著降低海馬中doublecortin陽性神經(jīng)元數(shù)目，且糖皮質(zhì)激素導(dǎo)致的海馬神經(jīng)元減少以II型doublecortin陽性神經(jīng)元為主,，而I型doublecortin陽性神經(jīng)元不受影響,。
免疫組織化學(xué)染色可見黃岑苷干預(yù)后慢性應(yīng)激模型大鼠海馬齒狀回doublecortin陽性表達(dá)
黃岑苷可顯著提高糖皮質(zhì)激素誘導(dǎo)的慢性應(yīng)激模型大鼠海馬中I型和II型doublecortin陽性神經(jīng)元數(shù)目。此外,，黃岑苷還能逆轉(zhuǎn)糖皮質(zhì)激素注射可引起doublecortin陽性神經(jīng)元樹突形態(tài)發(fā)生萎縮,。
作者認(rèn)為，黃岑苷具有促進(jìn)成體動(dòng)物海馬神經(jīng)發(fā)生的作用,，可能使其在改善認(rèn)知功能和情緒調(diào)節(jié)中有潛在的治療作用和臨床應(yīng)用前景,。
該結(jié)果發(fā)表在《中國神經(jīng)再生研究（英文版）》(Neural Regeneration Research)雜志2013年2月第6期。(生物谷Bioon.com)
DOI: 10.3969/j.issn.1673-5374.2013.06.002
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Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats
Xinghua Jiang, Junmei Xu, Dingquan Zou, Lin Yang, Yaping Wang.
Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats. Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus. The reduced cell number caused by corticosterone was mainly due to the decrease of class II doublecortin-positive neurons, but the class I doublecortin-positive neurons were unaffected. Baicalin treatment increased the number of both class I and class II doublecortin-positive neurons. In addition, doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection, and this change was totally reversed by baicalin treatment. These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis
