《自然醫(yī)學(xué)》雜志刊登了弗吉尼亞大學(xué)免疫中心的報(bào)道，在急性病毒感染灶周圍發(fā)現(xiàn)CD8(+)和CD4(+)效應(yīng)T細(xì)胞，其具有抗炎作用,。
激活的抗原特異性T細(xì)胞可產(chǎn)生的各種效應(yīng)分子，在清除感染的同時(shí)，還可能產(chǎn)生炎癥和組織損傷,。
研究者發(fā)現(xiàn)，在急性流感病毒感染者肺部生成大量IL-10,，這大部分是由病毒特異性T細(xì)胞,、CD8（+）T細(xì)胞產(chǎn)生。這些T細(xì)胞周邊同時(shí)產(chǎn)生IL-10及致炎因子,，同時(shí)1型輔助T或1型細(xì)胞毒性T細(xì)胞特征,。值得注意的是,，抑制T細(xì)胞源性IL-10將加重肺部炎癥，導(dǎo)致致死性傷害,。
研究表明,，T細(xì)胞抗病毒時(shí)發(fā)揮監(jiān)督職能，即通過產(chǎn)生抗炎細(xì)胞因子,，調(diào)節(jié)流感感染引起的肺部炎癥和損傷程度,。這項(xiàng)研究對(duì)高致病性流感病毒感染有潛在的基礎(chǔ)價(jià)值。(生物谷Bioon.com)
生物谷推薦原始出處：
Nature Medicine 22 February 2009 | doi:10.1038/nm.1929
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
Jie Sun1, Rajat Madan2, Christopher L Karp2 & Thomas J Braciale1,3
1 Beirne B. Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Charlottesville, Virginia 22908, USA.
2 Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.
4 Departments of Microbiology and Pathology, University of Virginia, 409 Lane Road, Charlottesville, Virginia 22908, USA.
Activated antigen-specific T cells produce a variety of effector molecules for clearing infection but also contribute to inflammation and tissue injury. Here we report an anti-inflammatory property of antiviral CD8+ and CD4+ effector T cells (Teff cells) in the infected periphery during acute virus infection. We find that, during acute influenza infection, interleukin-10 (IL-10) is produced in the infected lungs in large amounts—exclusively by infiltrating virus-specific Teff cells, with CD8+ Teff cells contributing a larger fraction of the IL-10 produced. These Teff cells in the periphery simultaneously produce IL-10 and proinflammatory cytokines and express lineage markers characteristic of conventional T helper type 1 or T cytotoxic type 1 cells. Notably, blocking the action of the Teff cell–derived IL-10 results in enhanced pulmonary inflammation and lethal injury. Our results show that antiviral Teff cells exert regulatory functions—that is, they fine-tune the extent of lung inflammation and injury associated with influenza infection by producing an anti-inflammatory cytokine. We discuss the potential implications of these findings for infection with highly pathogenic influenza viruses.
