真菌代謝產物的藥物發(fā)現--資源,、問題和策略
鄭維發(fā)*
徐州師范大學江蘇省藥用植物生物技術重點實驗室 徐州 221116
摘 要：本期菌物學報"真菌生物活性代謝產物的藥物發(fā)現?？?quot;刊登了7篇深度論述的綜述性文章,，19篇研究論文及2篇簡報,。內容涉及植物內生真菌產紫杉醇/紫杉烷的研究現狀及最新進展,、蟲草菌素產生菌的培養(yǎng)策略及其藥理學研究進展,、靈芝三萜和胞外多糖生物合成的調控策略,、淡水和海水真菌活性代謝產物研究進展等,。本期內容還涉及內生真菌的分離和鑒定,、海洋真菌的代謝產物分離、大型真菌的培養(yǎng),、代謝產物的分離及其藥理學研究,、酚類化合物測定方法、蛋白質組學以及生物轉化等研究,，基本體現了我國真菌代謝產物新藥發(fā)現研究的最新進展,，對真菌代謝產物合成調控、活性代謝產物分離和結構鑒定以及藥理學研究等都具有重要的參考價值,。
關鍵詞：真菌代謝產物,，新藥發(fā)現，資源,，問題 對策
生物谷推薦英文摘要：
Drug discovery from fungal metabolites: a review of the papers in this monographical issue of Mycosystema concerned with the natural resources, problems and strategies
ZHENG Wei-Fa*
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Xuzhou Normal University, Xuzhou 221116, China
Abstract: This monographical issue of Mycosystema contains 7 in-depth reviews, 19 research articles and 2 short communications on the latest and most important progress in the resources, problems and strategies for drug discovery from fungal metabolites. It covers the current progress and latest achievements on production of taxol by entophytic fungi, strategies and latest developments on culturing cordycepin-producing fungi, regulation strategies on biosynthesis of triterpenoids and extracellular polysaccharides produced by Ganoderma lucidum, current progress on bioactive metabolites from the fungi grown in fresh and sea water. This issue of Mycosystema also involves the isolation and identification of entophytic fungi, isolation of metabolites from sea-grown fungi, the culture for macro-fungi and isolation and bioassay of their metabolites, and research of methodology on determining polyphenols, proteomics and biotransformation. These reviews and research articles represent the most updated progress in drug discovery from fungal metabolites in China, and provide insights into up-regulation of bioactive fungal metabolites, isolation and structure identification of these metabolites as well as their pharmacological studies.
Key words: fungal metabolites, drug discovery, resources, problems, strategies
全文鏈接：http://journals.im.ac.cn/jwxtcn/ch/reader/view_abstract.aspx?file_no=11020151&flag=1
