型糖尿?。═1D）也被稱為青少年糖尿病,，它通常是由于胰腺中制造胰島素的貝塔細胞死亡導(dǎo)致的。如果沒有定期注射胰島素,，該病可能致命,。Douglas Melton及其同事開發(fā)了一種策略，用于重新編程成年成纖維細胞,，并把它們轉(zhuǎn)變成誘導(dǎo)多能干細胞,，從而利用患者自身的組織制造出貝塔細胞。
這些T1D干細胞與提供它們的來源的患者在遺傳上相匹配,，這可以有助于科學(xué)家研究該病的起源,。這組作者還成功地誘導(dǎo)T1D干細胞成為了制造胰島素的貝塔細胞——盡管這個過程效率不高。這組作者提出,，這項研究為用T1D患者的組織培養(yǎng)制造胰島素的貝塔細胞提供了概念驗證,。
這組作者說，如果與防止患者的免疫系統(tǒng)排斥這些新的干細胞的技術(shù)結(jié)合起來,，這些細胞可以用于移植,，盡管它們的主要價值首先是作為研究糖尿病如何以及為何發(fā)生的工具。（生物谷Bioon.com）
生物谷推薦原始出處：
PNAS August 31, 2009, doi: 10.1073/pnas.0906894106
Generation of pluripotent stem cells from patients with type 1 diabetes
René Maehra, Shuibing Chena, Melinda Snitowa, Thomas Ludwigb, Lisa Yagasakia, Robin Golandc, Rudolph L. Leibelc and Douglas A. Meltona,1
aDepartment of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and
bDepartment of Pathology and Cell Biology, and
cDivision of Molecular Genetics and Naomi Barrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.
