妊娠相關(guān)的乳腺癌,，大多預(yù)后不良,，而且臨床醫(yī)生和研究人員都同樣會忽略它。隨著分娩年齡增高這種趨勢,，可以預(yù)料,，并發(fā)于妊娠的乳腺癌事件將有所增加，關(guān)于說明這種預(yù)后不良的機(jī)理已經(jīng)有人提出,，包括暴露于不斷增加的激素環(huán)境,，可能無助于減少這些病人轉(zhuǎn)移機(jī)會增加，相反,，相對于懷孕前的這種改變,，妊娠期的乳房微環(huán)境可能促進(jìn)腫瘤生長；這種改變和促炎癥反應(yīng),、創(chuàng)傷愈合機(jī)制有關(guān)，且被認(rèn)為可能促進(jìn)腫瘤細(xì)胞的擴(kuò)散,。這種假設(shè)將進(jìn)一步論證,。

原文出處：Nature Reviews Cancer 6, 281-291 (April 2006) | doi:10.1038/nrc1839
Article series: Tumour Microenvironment
Pregnancy-associated breast cancer and metastasis
Abstract
Pregnancy-associated breast cancer, which has a poor prognosis, is often overlooked by clinicians and researchers alike. With the trend towards delayed child-bearing, an increase in the occurrence of breast cancer complicated by pregnancy is anticipated. The mechanisms that have been proposed to account for this poor prognosis, including increased hormone exposure, might not contribute significantly to the observed increase in metastasis seen in these patients. Instead, the mammary microenvironment might become tumour-promoting after pregnancy because of the remodelling of the mammary gland to its pre-pregnant state. This remodelling, which is associated with pro-inflammatory and wound-healing mechanisms, is proposed to support tumour-cell dissemination. This hypothesis will be discussed.