生物谷報道：本月9日,，紐約路透社報道,，據(jù)一項(xiàng)新的研究發(fā)現(xiàn),，一種經(jīng)重組的病毒可殺死惡性膠質(zhì)瘤
細(xì)胞，而不損害正常的細(xì)胞,。
天然的水泡性口膜炎病毒（VSV）是包括腦神經(jīng)膠質(zhì)瘤在內(nèi)的多種腫瘤細(xì)胞的有力殺手,，但也具有致命作用。據(jù)發(fā)表在美國國立癌癥研究所雜志上的研究結(jié)果稱,，用重組后的VSV感染14號惡性膠質(zhì)瘤細(xì)胞株,，可將其全部殺死,，并且未感染對照組的正常細(xì)胞株,。在攜帶有人惡性膠質(zhì)瘤的老鼠被注入重組VSV后腫瘤細(xì)胞明顯退化。在試劑經(jīng)靜脈注入后,，注入活的變異的VSV的老鼠比注入滅活病毒的老鼠存活時間顯著延長,。
這項(xiàng)研究意味著變異的VSV可以經(jīng)靜脈注射而無需直接注入腦內(nèi)，這為臨床上治療惡性膠質(zhì)瘤提供了一種新的可能手段,。同時,，較之手術(shù)這種方法更為簡單，而且如有必要,，病人在只需在門診多次接受注射,。盡管如此，這項(xiàng)研究結(jié)果仍需進(jìn)行進(jìn)一步的評估方可應(yīng)用于臨床試驗(yàn),。
英文原文：
Modified virus kills brain cancer in mice
NEW YORK (Reuters Health) - An engineered form of a virus can infect and kill malignant glioma cells while leaving normal cells unharmed, according to new research findings.
In its natural form, vesicular stomatitis virus (VSV) is a potent cancer-killer in a number of tumor cell types, including brain tumors called gliomas, but it can be lethal. "We engineered VSV to make it safer," Dr. Peter A. Forsyth, of the Clark Smith Integrative Brain Center at the University of Calgary, Canada, noted in comments to Reuters Health.
The researchers evaluated the susceptibility of 14 malignant glioma cell lines to infection and killing by the modified VSV. It infected and killed all 14 cell lines but had no effect in normal cell lines, the team reports in the Journal of the National Cancer Institute.
In mice carrying human malignant glioma, the tumor regressed markedly after it was injected with modified VSV. When the agent was given intravenously, mice treated with live mutant VSV survived significantly longer than those injected with dead virus.
This means, Forsyth pointed out, that mutant VSV "can be given intravenously rather than injected directly into the brain, so it's easier for patients than an operation and if needed it can be given several times as an outpatient."
Modified VSV "is promising in mice and we are excited about it," he told Reuters Health, "but we need to be cautious and continue to evaluate it before moving into a clinical trial."
