據(jù)4月11日的《科學(xué)》（Science）雜志報(bào)道說,，研究人員開發(fā)出了一種新藥,，它可以保護(hù)動(dòng)物的骨髓及胃腸道細(xì)胞不受放射療法的破壞，同時(shí)又不會(huì)減少放療對(duì)腫瘤細(xì)胞的效力,。盡管放療是治療癌癥的一種重要的武器,，但人們?nèi)匀恍枰梢韵拗戚椛鋵?duì)健康細(xì)胞毀滅性作用的藥物以減少放療可能的嚴(yán)重副作用。
根據(jù)Lyudmila Burdelya及其同事披露,，將這種叫做CBLB502的新藥在小鼠與猴子身上進(jìn)行測(cè)試發(fā)現(xiàn),，它是通過激活一種被某種類型癌細(xì)胞用來阻止細(xì)胞死亡的分子通道來發(fā)揮作用的。在輻射治療前的短時(shí)間內(nèi),，如果動(dòng)物接受一個(gè)單劑量該種藥物,，可以明顯降低輻射對(duì)動(dòng)物骨髓及胃腸道細(xì)胞的損傷，并延長動(dòng)物的存活時(shí)間,。研究人員說,，這種藥物可能還可以用作一種在輻射緊急情況下使用的保護(hù)劑,。例如，該藥可用于核電廠故障時(shí)的輻射爆炸或用在“臟彈”被引爆的時(shí)候,。（來源：EurekAlert!中文版）
生物谷推薦原始出處：
（Science），Vol. 320. no. 5873, pp. 226 - 230,，Lyudmila G. Burdelya,，Andrei V. Gudkov
An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
Lyudmila G. Burdelya,1* Vadim I. Krivokrysenko,2* Thomas C. Tallant,3 Evguenia Strom,2 Anatoly S. Gleiberman,2 Damodar Gupta,1 Oleg V. Kurnasov,4 Farrel L. Fort,2 Andrei L. Osterman,4 Joseph A. DiDonato,3 Elena Feinstein,2 Andrei V. Gudkov1,2
The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a polypeptide drug derived from Salmonella flagellin that binds to Toll-like receptor 5 (TLR5) and activates nuclear factor–B signaling. A single injection of CBLB502 before lethal total-body irradiation protected mice from both gastrointestinal and hematopoietic acute radiation syndromes and resulted in improved survival. CBLB502 injected after irradiation also enhanced survival, but at lower radiation doses. It is noteworthy that the drug did not decrease tumor radiosensitivity in mouse models. CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies.
1 Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
2 Cleveland BioLabs, Inc. (CBLI), Buffalo, NY14203, USA.
3 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
4 Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
