美國加利福尼亞州圣迭戈大學(xué)的一個研究小組日前表示,，腳趾甲可以成為診斷肺癌的先兆。
據(jù)悉,，他們通過研究腳趾甲中尼古丁的含量發(fā)現(xiàn),，高尼古丁含量的人得肺癌的風(fēng)險，比低含量的人高出三倍,。
而令人震驚的是,，在接受試驗的人中，有些人腳趾甲中尼古丁含量高,，卻從未有吸煙的歷史,。專家稱，這證明吸二手煙對人體的危害巨大,。
人的腳趾甲每年只會增長一厘米,，這一增長速度比手指甲要慢得多，因此,，從腳趾甲中更能判斷出是否受過尼古丁的侵害,。
該研究小組曾花費了12年的時間用來跟蹤記錄850人的健康狀況,，他們發(fā)現(xiàn)腳趾甲中的尼古丁含量過高還會增加心臟病的發(fā)病率。
據(jù)世界衛(wèi)生組織的統(tǒng)計,，全球每年估計有120萬以上的新發(fā)肺癌病例,，死亡約110萬人，平均每隔30秒就有人死于肺癌,，而90%的肺癌是由吸煙引起的,。（生物谷Bioon.com）
生物谷推薦原文出處：
Am. J. Epidemiol. (2011) doi: 10.1093/aje/kwq446
Toenail Nicotine Level as a Novel Biomarker for Lung Cancer Risk
Wael K. Al-Delaimy* and Walter C. Willett
Abstract
The objective of this US study was to assess the association of toenail nicotine level as a novel biomarker with lung cancer risk independent of reported smoking history. A nested case-control study of 210 male lung cancer cases and 630 matched controls aged 40–75 years participating in the Health Professionals Follow-up Study was conducted. Toenail samples collected in 1987 were analyzed for nicotine levels, and incident lung cancer cases were diagnosed between 1988 and 2000. Mean toenail nicotine level among cases was 0.95 ng/mg compared with 0.25 ng/mg among controls (P < 0.0001). In univariate analyses, the relative risk of lung cancer for the highest versus lowest quintiles of toenail nicotine level was 10.50 (95% confidence interval: 5.61, 19.64; P for trend < 0.0001). When the authors adjusted for pack-years from reported smoking history in multivariate analyses, the relative risk for toenail nicotine levels in the highest quintile was still significant in predicting lung cancer risk: 3.57 (95% confidence interval: 1.73, 7.37; P for trend < 0.0001). In conclusion, the toenail nicotine biomarker was found to be a strong predictor of lung cancer independent of smoking history, suggesting that the adverse effects of cigarette smoke may be underestimated in studies based on smoking history only.
