平時缺乏體育鍛煉、肥胖,、高血壓,、高膽固醇、吸煙,、糖尿病等因素都會誘發(fā)冠心病,。在美國，因冠心病導致的死亡率一直居高不下,。
同樣,，前列腺癌是美國男性第二大致死性癌癥類型。每年有240,000新增前列腺癌男性患者,，每年有34,000前列腺癌患者死亡,。
科學家們一直在探究這兩種高發(fā)病--冠心病和前列腺癌之間是否有聯(lián)系，因為如果一旦確定心血管疾病是前列腺癌致病的危險因素,，那么我們或許可以通過改變生活方式來一定程度上抑制腫瘤的發(fā)生發(fā)展,。但研究結(jié)果卻不盡如人意?？蒲腥藛T一直無法肯定那些引發(fā)冠心病的不良生活習慣會不會也導致前列腺癌的發(fā)生,。
近日，由Duke癌癥研究所研究人員進行的一項前列腺藥物試驗的大樣本分析研究中,，研究者發(fā)現(xiàn)冠心病和前列腺癌之間有著顯著相關(guān)性,，這一研究結(jié)果提示這兩種疾病也許有相同的致病因素。相關(guān)研究論文發(fā)表在Cancer Epidemiol Biomarkers Prev雜志,。
在Duke癌癥研究所研究人員進行的持續(xù)四年的隨機試驗中,，工作者運用6,390名前列腺癌男性患者資料去評估抗腫瘤藥物Dutasteride對前列腺癌的作用。前列腺癌患者在分別在第二年和第四年兩年進行了兩次前列腺生物活檢,，檢測了PSA水平,。同時研究人員收集了患者詳細的疾病史、體重、酒精攝入情況,、藥物使用等因素的信息,。
在6,390名前列腺癌男性患者中，有547人有冠心病史,。這些有冠心病史的前列腺癌男性患者PSA水平基線較高，同時患有糖尿病等代謝疾病,。結(jié)果證實了冠心病使得男性患前列腺癌的風險增加了35%,，并且之一風險率隨著年齡的增長而增加。
研究人員表示：我們或許可以改變不良的生活習慣,，控制冠心病發(fā)生的因素如高血壓,、糖尿病等從而能降低我們患前列腺癌的風險。(生物谷 Bioon.com)
doi:10.1158/1055-9965.EPI-11-1017
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Prostate Cancer Risk in Men with Baseline History of Coronary Artery Disease: Results from the REDUCE study
Jean-Alfred Thomas1,*,Leah Gerber2,Lionel L. Banez3,Daniel M. Moreira4, et al.
Background:Coronary artery disease (CAD) and prostate cancer (PCa) are not only common diseases, but share many risk factors. To date, only a few studies have explored the relationship between CAD and PCa risk, with conflicting results. Methods:The 4-year REDUCE study tested dutasteride 0.5 mg daily for PCa risk reduction in men with PSA of 2.5-10.0 ng/mL and a negative biopsy. Among men who underwent at least one on-study biopsy (n=6,729; 82.8%), the association between CAD and overall PCa risk and disease grade was examined using logistic and multinomial logistic regression adjusting for clinicopathological features, respectively. Results:Overall, 547 men (8.6%) had a history of CAD. Men with CAD were significantly older and had higher BMI, PSA and larger prostate volumes and were more likely to have diabetes, hypertension, and hypercholesterolemia and take aspirin and statins. On multivariate analysis, CAD was associated with a 35% increased risk of PCa diagnosis (OR: 1.35, 95% CI: 1.08-1.67, p=0.007), while elevating risk of both low- (OR: 1.34, 95% CI: 1.05-1.73, p=0.02), and high-grade disease (OR: 1.34, 95% CI: 0.95-1.88, p=0.09). Conclusions:In a post-hoc hypothesis developing secondary analysis of the REDUCE study, CAD was significantly associated with increased PCa diagnosis. Impact: If confirmed in other studies, this suggests CAD may be a novel PCa risk factor and suggests common shared etiologies. Whether lifestyle changes shown to reduce CAD risk (i.e. weight loss, exercise, cholesterol reduction, etc.) can reduce PCa risk, warrants further study.
