日前，美國哈佛大學(xué)醫(yī)學(xué)院研究人員完成的研究顯示,，常喝含咖啡因的咖啡有助于降低患常見皮膚癌——基底細(xì)胞癌的風(fēng)險,。相關(guān)研究報告發(fā)表在美國《癌癥研究》（Cancer Research）雜志上。
研究人員分析了參加“健康職業(yè)跟蹤研究”和“護(hù)士健康研究”的11.2萬人為期20多年的數(shù)據(jù)后發(fā)現(xiàn),，每天飲用3杯以上含咖啡因咖啡的女性患基底細(xì)胞癌的風(fēng)險比每月飲用不到一杯者低21%,；對類似的男性而言，風(fēng)險降低10%,。
他們還發(fā)現(xiàn),，經(jīng)常攝入含咖啡因的茶或巧克力也可以發(fā)揮同樣功效，但不能降低患鱗狀細(xì)胞癌,、黑素瘤及其他皮膚癌的風(fēng)險,；飲用不含咖啡因的咖啡與患基底細(xì)胞癌的風(fēng)險之間沒有關(guān)聯(lián)。
研究人員表示,，此前的小鼠試驗表明,，咖啡因能夠抑制腫瘤增長，這項研究表明咖啡因在人體中或許也能發(fā)揮類似作用,。
基底細(xì)胞癌是最常見的皮膚惡性腫瘤,，常發(fā)作于面部。在國外,，半數(shù)以上皮膚癌患者患的是基底細(xì)胞癌,。美國國家癌癥研究所的數(shù)據(jù)顯示，美國每年約有百萬人接受基底細(xì)胞癌治療,。（生物谷Bioon.com）
doi:10.1158/0008-5472.CAN-11-3511
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Increased Caffeine Intake Is Associated with Reduced Risk of Basal Cell Carcinoma of the Skin
Fengju Song1,4, Abrar A. Qureshi1,2, and Jiali Han1,2,3
Studies in animals suggest that caffeine administration helps prevent squamous cell skin cancer development, but there have been limited epidemiologic studies on the association between caffeine consumption and skin cancer risk. Using data from the Nurses' Health Study and the Health Professionals Follow-up Study, we prospectively examined risks of basal cell carcinoma (BCC, 22,786 cases), squamous cell carcinoma (SCC, 1,953 cases), and melanoma (741 cases) in relation to caffeine intake. Cox proportional hazard models were used to calculate relative risks (RR) and 95% confidence intervals (CI). The amount of caffeine intake from all dietary sources was inversely associated with BCC risk. Compared with the lowest quintile, the highest quintile had the lowest risk (RR, 0.82 in women; 95% CI:,0.77–0.86 and RR, 0.87 in men; 95% CI, 0.81–0.94; Ptrend < 0.0001 in both). A significant inverse association was also found between caffeinated coffee consumption and BCC risk. Compared with individuals who consumed caffeinated coffee less than 1 cup per month, women who consumed more than 3 cups/d had the lowest risk (RR, 0.79; 95% CI, 0.74–0.85; Ptrend < 0.0001) and the RR for men was 0.90 (95% CI, 0.80–1.01; Ptrend = 0.003). Caffeine from other dietary sources (tea, cola, and chocolate) was also inversely associated with BCC risk. Decaffeinated coffee consumption was not associated with a similar decrease in BCC risk. In contrast, caffeine intake was not found to be inversely associated with risks of SCC or melanoma. Our findings argue that caffeine intake in men and women is inversely associated with risk of BCC.
