美國賓夕法尼亞大學(xué)的研究人員10月4日?qǐng)?bào)告說,，他們以小鼠為模型進(jìn)行的動(dòng)物研究顯示,，綠茶中的一種名為EGCG的兒茶素可以抑制小鼠體重增加，該物質(zhì)有望成為對(duì)抗肥胖的新制劑,。
研究人員在美國《肥胖》雜志網(wǎng)絡(luò)版上介紹說,，他們給兩組小鼠喂食同樣數(shù)量的高脂食物，其中一組同時(shí)喂食EGCG兒茶素,。研究人員發(fā)現(xiàn),，EGCG組小鼠增加的體重比另一組低45%，前者排泄物中的脂質(zhì)比另一組高出約30%,，這意味著EGCG兒茶素抑制了小鼠對(duì)脂肪的吸收,。
領(lǐng)導(dǎo)這項(xiàng)研究的賓夕法尼亞大學(xué)助理教授喬舒亞-蘭伯特說，EGCG兒茶素似乎既能增強(qiáng)小鼠對(duì)脂肪的利用,，同時(shí)也降低小鼠對(duì)脂肪的吸收,。
蘭伯特指出，一個(gè)人可能每天需要喝10杯綠茶才能吸取與上述小鼠攝入量相當(dāng)?shù)腅GCG兒茶素,，不過近來有其他研究顯示,，每天喝幾杯綠茶就有助于控制體重。
“盡管目前與喝綠茶有關(guān)的體重?cái)?shù)據(jù)不是很多,，但仍可表明,，與不喝綠茶相比，每天只需飲用一杯以上的綠茶就能看到對(duì)體重帶來的影響,，”蘭伯特說。（生物谷 Bioon.com）
doi:10.1038/oby.2011.139
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(|[minus]|)-Epigallocatechin-3-gallate Inhibits Pancreatic Lipase and Reduces Body Weight Gain in High Fat-Fed Obese Mice
Kimberly A. Grove, Sudathip Sae-tan, Mary J. Kennett, Joshua D. Lambert
Tea (Camellia sinensis, Theaceae) has been shown to have obesity preventive effects in laboratory studies. We hypothesized that dietary epigallocatechin-3-gallate (EGCG) could reverse metabolic syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of pancreatic lipase (PL). Following treatment with 0.32% EGCG for 6 weeks, a 44% decrease in body weight (BW) gain in high fat-fed, obese mice (P < 0.01) was observed compared to controls. EGCG treatment increased fecal lipid content by 29.4% (P < 0.05) compared to high fat-fed control, whereas in vitro, EGCG dose-dependently inhibited PL (IC50 = 7.5 µmol/l) in a noncompetitive manner with respect to substrate concentration. (−)-Epicatechin-3-gallate exhibited similar inhibitory activity, whereas the nonester-containing (−)-epigallocatechin did not. In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to inhibition of PL by EGCG.
