生物谷報(bào)道：目前,，科學(xué)家已揭開(kāi)人們?cè)谏聿某叽缟嫌忻黠@差異的謎底,。一項(xiàng)國(guó)際范圍內(nèi)的基因組研究發(fā)現(xiàn)了影響身高的10個(gè)新的基因,，從而提供了對(duì)人類(lèi)成長(zhǎng)很重要的生物學(xué)方面的新視角,。
這項(xiàng)分析得出了一些生物學(xué)方面的深刻發(fā)現(xiàn),。幾個(gè)可識(shí)別的基因被名為let-7的小分子 RNA當(dāng)作靶點(diǎn),，從而影響了其他基因的秩序,，基因之間的這種聯(lián)系直到現(xiàn)在才被發(fā)現(xiàn)。一些其他的單核苷酸多態(tài)性(SNPs)可能影響染色體周?chē)牡鞍踪|(zhì),，影響染色質(zhì)的結(jié)構(gòu),。而且，這項(xiàng)研究結(jié)果可能與患有遺傳性生長(zhǎng)疾病或是有骨骼發(fā)育問(wèn)題的病人有關(guān),，因?yàn)橐恍┳钚掳l(fā)現(xiàn)的基因具有與反常的骨骼發(fā)育有關(guān)的罕見(jiàn)變異,。要完全闡明與身高有關(guān)的生長(zhǎng)基因序列背后的生物學(xué)機(jī)制，還需要進(jìn)一步的功能性研究,。
這項(xiàng)整合分析是在超過(guò)2.6萬(wàn)個(gè)研究參與者的數(shù)據(jù)基礎(chǔ)上產(chǎn)生的,，它刊登在《自然—遺傳學(xué)》（Nature Genetics）雜志上。（生物谷www.bioon.com）
生物谷推薦原始出處：
Nature Genetics,，doi:10.1038/ng.125,，Guillaume Lettre，Joel N Hirschhorn
Identification of ten loci associated with height highlights new biological pathways in human growth
Guillaume Lettre1,2, Anne U Jackson3,25, Christian Gieger4,5,25, Fredrick R Schumacher6,7,25, Sonja I Berndt8,25, Serena Sanna3,9,25, Susana Eyheramendy4,5, Benjamin F Voight1,10, Johannah L Butler2, Candace Guiducci1, Thomas Illig4, Rachel Hackett1, Iris M Heid4,5, Kevin B Jacobs11, Valeriya Lyssenko12, Manuela Uda9, The Diabetes Genetics Initiative24, FUSION24, KORA24, The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial24, The Nurses' Health Study24, SardiNIA24, Michael Boehnke3, Stephen J Chanock13, Leif C Groop12,14, Frank B Hu6,7,15, Bo Isomaa16,17, Peter Kraft7, Leena Peltonen1,18,19, Veikko Salomaa20, David Schlessinger21, David J Hunter1,6,7,15, Richard B Hayes8, Gonçalo R Abecasis3, H-Erich Wichmann4,5, Karen L Mohlke22 & Joel N Hirschhorn1,2,23
Abstract
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 10- 7 to 8 10- 22). Together, these 12 loci account for 2% of the population variation in height. Individuals with 8 height-increasing alleles and 16 height-increasing alleles differ in height by 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait.
