生物谷報(bào)道：日前,，一個(gè)國際科學(xué)研究組在德國波恩大學(xué)成功發(fā)現(xiàn)了脫發(fā)發(fā)病的關(guān)鍵因素。經(jīng)過6年的研究他們成功地識(shí)別出一種罕見的遺傳類型單一性少毛癥的真兇,?？茖W(xué)家首次發(fā)現(xiàn)一種在頭發(fā)生長(zhǎng)中起重要作用的受體，他們希望通過這項(xiàng)研究成果產(chǎn)生新的治療方法,，用來解決多方面的脫發(fā)問題,。
該項(xiàng)目負(fù)責(zé)人波恩大學(xué)人類遺傳學(xué)會(huì)Regina Betz博士在總結(jié)研究結(jié)果時(shí)說：“盡管單一性少毛癥是非常罕見的，但它有可能是證明我們尋找到頭發(fā)生長(zhǎng)機(jī)制的關(guān)鍵,。”無論男性和女性都會(huì)受到這種遺傳疾病影響,，受害者一般會(huì)在兒童時(shí)期變成禿頂，脫發(fā)的過程會(huì)隨著年齡的增加而加快,，尤其是頭皮周圍部分,。
科學(xué)家們?cè)谶z傳缺陷研究項(xiàng)目中成功地檢驗(yàn)出了少毛癥的發(fā)病原因。遺傳缺陷阻止了頭發(fā)毛囊細(xì)胞表面的受體組織正常形成,。波恩大學(xué)生命與大腦研究中心的遺傳醫(yī)學(xué)教授Markus博士解釋說：“有缺陷的受體組織屬于被稱為G蛋白偶聯(lián)受體一類,。這是一個(gè)好消息，因?yàn)樗鼈兲貏e適合藥物療法,。”研究人員可以識(shí)別出一種生長(zhǎng)在頭發(fā)毛囊受體上的內(nèi)生性信息體,，這為發(fā)展一種新的有效療法創(chuàng)造了機(jī)會(huì)。波恩藥理學(xué)和毒物學(xué)研究所Ivar博士說：“我們現(xiàn)在可以有選擇的尋找一種相關(guān)的物質(zhì)用來治療脫發(fā),。”令人興奮的是,，這種藥可能會(huì)對(duì)遭受不同類型脫發(fā)的患者有很大的益處。（科技日?qǐng)?bào)）
生物谷推薦原始出處：
Nature Genetics 40, 329 - 334 (2008)
Published online: 24 February 2008 | doi:10.1038/ng.84
G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Sandra M Pasternack1, Ivar von Kügelgen2, Khalid Al Aboud3, Young-Ae Lee4,5, Franz Rüschendorf5, Katrin Voss6, Axel M Hillmer7, Gerhard J Molderings2, Thomas Franz8, Alfredo Ramirez9,10,11, Peter Nürnberg11,12, Markus M Nöthen1,7 & Regina C Betz1
Abstract
Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an autosomal recessive form of this disorder to chromosome 13q14.11–13q21.33, and identified homozygous truncating mutations in P2RY5, which encodes an orphan G protein–coupled receptor. Furthermore, we identified oleoyl-L--lysophosphatidic acid (LPA), a bioactive lipid, as a ligand for P2Y5 in reporter gene and radioligand binding experiments. Homology and studies of signaling transduction pathways suggest that P2Y5 is a member of a subgroup of LPA receptors, which also includes LPA4 and LPA5. Our study is the first to implicate a G protein–coupled receptor as essential for and specific to the maintenance of human hair growth. This finding may provide opportunities for new therapeutic approaches to the treatment of hair loss in humans.
Institute of Human Genetics, University of Bonn, Bonn 53111, Germany.
Department of Pharmacology, University of Bonn, Bonn 53113, Germany.
Department of Dermatology, King Faisal Hospital, Makkah 5592, Saudi Arabia.
Department of Pediatric Pneumology and Immunology, Charité, Humboldt-University Berlin 13353, Berlin, Germany.
Max Delbrück Center for Molecular Medicine, Berlin 13092, Germany.
Department of Human Genetics, University of Würzburg, Würzburg 97074, Germany.
Department of Genomics, Life and Brain Center, University of Bonn, Bonn 53127, Germany.
Department of Anatomy, University of Bonn, Bonn 53115, Germany.
Institute for Genetics, University of Cologne, Cologne 50674, Germany.
Institute of Human Genetics, University of Cologne, Cologne 50931, Germany.
Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany.
Cologne Center for Genomics, University of Cologne, Cologne 50674, Germany.
Correspondence to: Regina C Betz1 e-mail: [email protected]
