基因調(diào)控網(wǎng)絡(luò)(GRN)這個(gè)概念在關(guān)于動(dòng)物身體平面的形成過程的研究中的應(yīng)用,,是系統(tǒng)生物學(xué)何以能夠?yàn)榛钌锏幕蚪M調(diào)控序列是如何工作的提供因果關(guān)系解釋的一個(gè)例子。在本期Nature的一篇Review文章中,,Eric Davidson描繪了GRN的一個(gè)畫面,,這個(gè)畫面所依據(jù)的是對(duì)數(shù)量雖少、但卻不斷增長的,、目前已確認(rèn)的GRN所進(jìn)行的研究工作,,同時(shí)他還強(qiáng)調(diào)了分子生物功能與基因組之間的聯(lián)系。(生物谷Bioon.com)
生物谷推薦原文出處:
Nature doi:10.1038/nature09645
Emerging properties of animal gene regulatory networks
Gene regulatory networks (GRNs) provide system level explanations of developmental and physiological functions in the terms of the genomic regulatory code. Depending on their developmental functions, GRNs differ in their degree of hierarchy, and also in the types of modular sub-circuit of which they are composed, although there is a commonly employed sub-circuit repertoire.