美國一項研究顯示,，調(diào)查壓力如何影響腸道的美國研究人員，偶然發(fā)現(xiàn)1種強烈的化學(xué)物質(zhì),，而這種化學(xué)物質(zhì)能幫助小鼠重新長出毛發(fā)。研究論文2月16日在線發(fā)表在《公共科學(xué)圖書館·綜合》（PLoS ONE）雜志上,。
實驗發(fā)現(xiàn),，藉由阻斷壓力荷爾蒙能幫助小鼠重新長出毛發(fā)，效果比使用治療禿頭的生發(fā)藥水成分敏諾西代還要好,，不過目前還沒經(jīng)人體實驗,。
研究指出，美國加州大學(xué)洛杉磯分校以及退伍軍人輔導(dǎo)會發(fā)現(xiàn)這項化學(xué)物質(zhì)“完全出于意外”,。
科學(xué)家將小鼠基因改造,，用意是讓這群突變小鼠體內(nèi),，分泌出過多的促腎上腺皮質(zhì)激素釋放因子（CRF）,，讓他們因長期處在壓力下使背部毛發(fā)脫落,。接下來在小鼠體內(nèi)注射1種稱做astressin-B的化合物,，目的是阻斷CRF，研究人員再去看腸胃道功能是否有所影響,。
盡管一開始并看不出效果,，研究人員仍持續(xù)5天療程,，完成腸胃道檢驗后，再把他們放回和有毛發(fā)的對照組一起,。
經(jīng)過3個月,，研究人員回頭去找這些歷經(jīng)長期高壓的小鼠，然而卻發(fā)現(xiàn),，他們無法分辨實驗組與對照組，因為這些小鼠的背部都已長出毛,。
研究還發(fā)現(xiàn),，阻斷CRF不僅幫助生出毛發(fā),，似乎還有助維持發(fā)色不變灰的功效。
更讓研究人員感到詫異的是,，僅僅5天的療程，居然可讓生發(fā)的效果持續(xù)長達4個月,。（生物谷Bioon.com）
生物谷推薦原文出處：
PLoS ONE 6(2): e16377. doi:10.1371/journal.pone.0016377
CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice
Lixin Wang1#, Mulugeta Million1#*, Jean Rivier2, Catherine Rivier2, Noah Craft3, Mary P. Stenzel-Poore4, Yvette Taché1
Corticotropin-releasing factor (CRF) signaling pathways are involved in the stress response, and there is growing evidence supporting hair growth inhibition of murine hair follicle in vivo upon stress exposure. We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing's syndrome and chronic stress, including alopecia. The non-selective CRF receptors antagonist, astressin-B (5 μg/mouse) injected peripherally once a day for 5 days in 4–9 months old CRF-OE alopecic mice induced pigmentation and hair re-growth that was largely retained for over 4 months. In young CRF-OE mice, astressin-B prevented the development of alopecia that occurred in saline-treated mice. Histological examination indicated that alopecic CRF-OE mice had hair follicle atrophy and that astressin-B revived the hair follicle from the telogen to anagen phase. However, astressin-B did not show any effect on the elevated plasma corticosterone levels and the increased weights of adrenal glands and visceral fat in CRF-OE mice. The selective CRF2 receptor antagonist, astressin2-B had moderate effect on pigmentation, but not on hair re-growth. The commercial drug for alopecia, minoxidil only showed partial effect on hair re-growth. These data support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress.
