生物谷報(bào)道：觸覺是由皮膚中的很多機(jī)械受體調(diào)控的。現(xiàn)在,，研究人員首次在一種脊椎動(dòng)物身上發(fā)現(xiàn)了一種分子,，該分子的功能是這一初級(jí)傳導(dǎo)活動(dòng)所必需的,。這一研究結(jié)果發(fā)表在最新一期的《Nature》上,。
在活體試驗(yàn)中,，膜蛋白SLP3（stomatin-like protein 3）是小鼠的機(jī)械受體功能所必需的，也是機(jī)械傳感通道發(fā)揮功能所必需的,。這一蛋白是哺乳動(dòng)物中mec-2蛋白的同系物,。SLP3還調(diào)控以前被發(fā)現(xiàn)與觸覺相關(guān)的離子通道,，所以它可能是哺乳動(dòng)物觸覺傳感器的一個(gè)亞單元。
FIGURE 1. Mechanically insensitive primary afferents.
a, The electrical search protocol is illustrated in the insets. Note the increase in mechanically insensitive A fibres in SLP3-/- mice (asterisk, P < 0.05 (A ); two asterisks, P < 0.005 (A ); 2 test), but no change in mechanosensitive C fibres; n = 18–31 mice per genotype. WT, wild-type. b, Using the illustrated mechanical search protocol no significant difference (P > 0.05; 2 test) in the proportions of mechanoreceptor types in A , A (AM) and C fibres was found; n = 8–10 mice per genotype. RA, rapidly adapting; SA, slowly adapting; C-M, C-mechanonociceptor; C-MH, C-mechanoheat nociceptor. c, Increase in the proportion of RAM fibres in SLP3-/- with a tap response (two asterisks, P < 0.005; 2 test). d, Normal stimulus response functions of C-fibre nociceptors in SLP3-/- mice. Black circles, SLP3+/+; red triangles, SLP3-/-. The number of neurons recorded is indicated in parentheses in each panel. Error bars indicate s.e.m.
原文出處：
Volume 445 Number 7124 January 11,，2007
A stomatin-domain protein essential for touch sensation in the mouse p206
Christiane Wetzel, Jing Hu, Dieter Riethmacher, Anne Benckendorff, Lena Harder, Andreas Eilers, Rabih Moshourab, Alexey Kozlenkov, Dominika Labuz, Ombretta Caspani, Bettina Erdmann, Halina Machelska, Paul A. Heppenstall and Gary R. Lewin
doi:10.1038/nature05394
First paragraph | Full Text | PDF (383K) | Supplementary information
See also: Editor's summary
相關(guān)基因：
mec-2
MEChanosensory abnormality [Caenorhabditis elegans]
Other Aliases: F14D12.4
Other Designations: MEChanosensory abnormality family member (mec-2)
Chromosome: X
GeneID: 180826
