生物谷報(bào)道：突觸的形成對建立神經(jīng)網(wǎng)絡(luò)十分重要,。突觸形成是一個(gè)復(fù)雜的過程。TRP通道是一類六次跨膜的非選擇性陽離子通道,。它們在進(jìn)化中高度保守,，在哺乳動(dòng)物體內(nèi)廣泛表達(dá),，參與了許多重要的生理學(xué)功能，如對溫度,、痛覺,、聽覺的感知以及受精,。TRPC通道是TRP的一個(gè)亞家族，在人的中樞神經(jīng)系統(tǒng)中表達(dá)豐富,，但其生理功能卻知之較少,。
神經(jīng)科學(xué)國家重點(diǎn)實(shí)驗(yàn)室王以政研究員領(lǐng)導(dǎo)的研究組,，發(fā)現(xiàn)TRPC6通道促進(jìn)興奮性突觸的形成，提高小鼠空間學(xué)習(xí)和記憶能力,。該研究組的博士研究生周健和杜婉璐等研究發(fā)現(xiàn)TRPC6通道在興奮性突觸,，特別是突觸后大量表達(dá),，促進(jìn)神經(jīng)元樹突棘密度的增加。樹突棘是神經(jīng)元突起上的一種微小結(jié)構(gòu),，是形成興奮性突觸的重要位點(diǎn)。他們發(fā)現(xiàn)TRPC6通道可以促進(jìn)興奮性突觸的密度,。突觸作為腦內(nèi)神經(jīng)元之間相互"對話"重要的結(jié)構(gòu),，它們數(shù)目的增加可影響學(xué)習(xí)和記憶,。為了證實(shí)這種想法，兩位研究生構(gòu)建和培育了TRPC6轉(zhuǎn)基因的小鼠,。通過行為學(xué)的實(shí)驗(yàn)，發(fā)現(xiàn)該小鼠空間學(xué)習(xí)和記憶能力得到了大幅度的提高,。該項(xiàng)研究成果于2008年5月30日在線發(fā)表在神經(jīng)科學(xué)重要期刊《自然—神經(jīng)學(xué)》（Nature Neuroscience）上,。
該工作揭示了TRPC通道對于興奮性突觸發(fā)育和學(xué)習(xí)記憶能力所起到的重要作用。這是該實(shí)驗(yàn)室繼去年在Nature Neuroscience報(bào)道該通道促進(jìn)神經(jīng)元存活后,，對TRPC通道功能的又一發(fā)現(xiàn),。對理解學(xué)習(xí)記憶機(jī)制，提供了新的思路和啟發(fā),。（生物谷援引國家重點(diǎn)實(shí)驗(yàn)室網(wǎng)站）
生物谷推薦原始出處：
Brief Communication abstract
Nature Neuroscience
Published online: 30 May 2008 | doi:10.1038/nn.2127
Critical role of TRPC6 channels in the formation of excitatory synapses
Jian Zhou1,2,3, Wanlu Du1,2,3, Kechun Zhou1,2, Yilin Tai1,2, Hailan Yao1,2, Yichang Jia1,2, Yuqiang Ding1 & Yizheng Wang1
The transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB–dependent pathway. TRPC6 transgenic mice showed enhancement in spine formation, and spatial learning and memory in Morris water maze. These results reveal a previously unknown role of TRPC6 in synaptic and behavioral plasticity.
Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai Institutes of Biological Sciences, State Key Laboratory of Neuroscience, Shanghai 200031, China.
The Graduate School, Chinese Academy of Science, Shanghai 200031, China.
These authors contributed equally to this work.
Correspondence to: Yizheng Wang1 e-mail: [email protected]
