美國(guó)研究人員日前在《神經(jīng)學(xué)雜志》(Journal of Neuroscience)上發(fā)表報(bào)告說,,母親能毫不費(fèi)力地把她們的經(jīng)驗(yàn)遺傳給孩子。這項(xiàng)研究顯示,,幼鼠能夠繼承它們母親懷孕之前獲得的有益知識(shí),。
報(bào)道說,研究發(fā)現(xiàn),,在一個(gè)有玩具和其他刺激性物品豐富的環(huán)境里成長(zhǎng)的幼鼠,,在長(zhǎng)大后能把學(xué)到的知識(shí)傳給它們的幼崽。研究人員還發(fā)現(xiàn),,如果給剛出生的幼崽更換父母,,只要幼崽的生母(而不是養(yǎng)父母)在有玩具的環(huán)境里長(zhǎng)大,,它們的幼崽仍然可以學(xué)習(xí)得更好。
波士頓塔夫茨大學(xué)藥學(xué)院的生物化學(xué)教授拉里·法伊格說:“你能在一定程度上繼承你父母某些方面的經(jīng)驗(yàn),。”
法伊格還說:“這是母親傳給后代的一個(gè)保護(hù)性機(jī)制,。這些未來的鼠媽媽幾個(gè)月來一直在成長(zhǎng)。它們的大腦也在成長(zhǎng),,因此當(dāng)它們長(zhǎng)到可以懷孕時(shí),,這種效果仍然存在。”(生物谷Bioon.com)
生物谷推薦原始出處:
Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment
Junko A. Arai,1 * Shaomin Li,1 * Dean M. Hartley,2 and Larry A. Feig1
1Sackler School of Biomedical Sciences and Departments of Biochemistry and Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, and 2Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612
The idea that qualities acquired from experience can be transmitted to future offspring has long been considered incompatible with current understanding of genetics. However, the recent documentation of non-Mendelian transgenerational inheritance makes such a "Lamarckian"-like phenomenon more plausible. Here, we demonstrate that exposure of 15-d-old mice to 2 weeks of an enriched environment (EE), that includes exposure to novel objects, elevated social interactions and voluntary exercise, enhances long-term potentiation (LTP) not only in these enriched mice but also in their future offspring through early adolescence, even if the offspring never experience EE. In both generations, LTP induction is augmented by a newly appearing cAMP/p38 MAP kinase-dependent signaling cascade. Strikingly, defective LTP and contextual fear conditioning memory normally associated with ras-grf knock-out mice are both masked in the offspring of enriched mutant parents. The transgenerational transmission of this effect occurs from the enriched mother to her offspring during embryogenesis. If a similar phenomenon occurs in humans, the effectiveness of one's memory during adolescence, particularly in those with defective cell signaling mechanisms that control memory, can be influenced by environmental stimulation experienced by one's mother during her youth.