科學(xué)家們發(fā)現(xiàn)，在學(xué)習(xí)過(guò)程中，大腦中與情感和學(xué)習(xí)相關(guān)的區(qū)域?qū)嶋H上有相當(dāng)多的協(xié)同作用,，這種相互間協(xié)同作用增強(qiáng)了記憶過(guò)程中的神經(jīng)細(xì)胞間的聯(lián)系,。新成果發(fā)表在日前在線出版的《自然—神經(jīng)學(xué)》期刊上。
Denis Pare和同事測(cè)量了大腦中與獎(jiǎng)賞性學(xué)習(xí)相關(guān)的多個(gè)活躍區(qū)域的信號(hào),。他們將主要目標(biāo)放在大腦中負(fù)責(zé)情緒調(diào)控的扁桃體結(jié)構(gòu)區(qū)域,，以及大腦中與學(xué)習(xí)相關(guān)的紋狀區(qū)域。他們發(fā)現(xiàn),，當(dāng)一種聲音和一種獎(jiǎng)賞分別單獨(dú)呈現(xiàn)時(shí),，大腦兩個(gè)區(qū)域的活動(dòng)節(jié)奏在聲音響起時(shí)的活動(dòng)并不協(xié)調(diào)。然而,，當(dāng)動(dòng)物們知道聲音的響起預(yù)示著即將來(lái)臨的獎(jiǎng)賞時(shí),，扁桃體區(qū)和紋狀區(qū)的活動(dòng)就變得更加協(xié)同。這種協(xié)同性對(duì)兩個(gè)區(qū)域來(lái)說(shuō)都很特別,，而且目前的科學(xué)文獻(xiàn)中沒(méi)有記載過(guò)其他的大腦區(qū)域有這種協(xié)同性,。
以前的研究顯示，當(dāng)兩種神經(jīng)元的點(diǎn)火同時(shí)發(fā)生時(shí),，這兩種神經(jīng)元間的聯(lián)絡(luò)被強(qiáng)化了,，因此，這種強(qiáng)化的聯(lián)系應(yīng)該是記憶力提高的機(jī)理所在,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Neuroscience 10 May 2009 | doi:10.1038/nn.2305
Coherent gamma oscillations couple the amygdala and striatum during learning
Andrei T Popescu1, Daniela Popa1 & Denis Paré1
The basolateral amygdala (BLA) mediates the facilitating effects of emotions on memory. The BLA's enhancing influence extends to various types of memories, including striatal-dependent habit formation. To shed light on the underlying mechanisms, we carried out unit and local field potential (LFP) recordings in BLA, striatum, auditory cortex and intralaminar thalamus in cats trained on a stimulus-response task in which the presentation of one of two tones predicted reward delivery. The coherence of BLA, but not of cortical or thalamic, LFPs was highest with striatal gamma activity, and intra-BLA muscimol infusions selectively reduced striatal gamma power. Moreover, coupling of BLA-striatal unit activity increased when LFP gamma power was augmented. Early in training, the rewarded and unrewarded tones elicited a modest increase in coherent BLA-striatal gamma. As learning progressed, this gamma coupling selectively increased in relation to the rewarded tone. Thus, coherent gamma oscillations coordinate amygdalostriatal interactions during learning and might facilitate synaptic plasticity.
1 Center for Molecular & Behavioral Neuroscience, Rutgers State University, Newark, New Jersey, USA.
