近日來(lái)自西安交通大學(xué)的研究人員在國(guó)際著名學(xué)術(shù)刊物《公共科學(xué)圖書館—綜合》（PLoS ONE）上發(fā)表了題目為“Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress”的研究論文,。
該論文的第一作者是西安交通大學(xué)附屬一院精神心理科馬現(xiàn)倉(cāng)副教授，通訊作者是高成閣教授和西安交通大學(xué)醫(yī)學(xué)院的黨永輝博士,。
既往研究證實(shí)應(yīng)激性生活事件是重癥抑郁（major depressive disorder）的重要易感因素之一,，給予嚙齒類動(dòng)物以長(zhǎng)期的難以預(yù)料的各種不威脅生存的應(yīng)激，可以引起類似人類的抑郁和焦慮樣行為,，這也是國(guó)際上通行的建立抑郁動(dòng)物模型的方法之一,，即為“慢性不可預(yù)期溫和應(yīng)激（chronic unpredictable mild stress, CUMS）”抑郁模型,。但是這一模型在小鼠的再現(xiàn)性比較低,，比較難以建立,。有文獻(xiàn)報(bào)道單獨(dú)飼養(yǎng)的成年雄性小鼠對(duì)同性的攻擊性增強(qiáng)。
該研究小組在國(guó)家自然科學(xué)基金的資助下,，利用小鼠的這一生物特性,，在常用各種應(yīng)激源中引入孤養(yǎng)以及隨機(jī)相互攻擊的應(yīng)激，成功建立小鼠CUMS模型,，并發(fā)現(xiàn)這一方法優(yōu)于使用其它常見溫和應(yīng)激,。這一結(jié)果,，對(duì)于成功建立抑郁小鼠模型具有重要啟示，對(duì)于一些臨床現(xiàn)象也有啟迪作用,。
該研究小組目前正在利用這一新的模型進(jìn)行抑郁癥神經(jīng)生物學(xué)機(jī)制和干預(yù)性治療的深入研究,。該文章的發(fā)表標(biāo)志著一附院精神心理科在抑郁癥的基礎(chǔ)研究方面邁上一個(gè)新的臺(tái)階。（生物谷Bioon.com）
生物谷推薦原文出處：
PLoS ONE doi:10.1371/journal.pone.0020955
Social Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress
Xian-cang Ma, Dong Jiang, Wen-hui Jiang, Fen Wang, Min Jia1, Jin Wu, Kenji Hashimoto, Yong-hui Dang, Cheng-ge Gao
Background
Accumulating epidemiological evidence shows that life event stressors are major vulnerability factors for psychiatric diseases such as major depression. It is also well known that social isolation in male mice results in aggressive behavior. However, it is not known how social isolation-induced aggression affects anxiety and depressive-like behavior in isolated male mice subjected to unpredictable chronic mild stress (CMS), an animal model of depression.
Methodology/Principal Findings
C57/B6 male mice were divided into 3 groups; non-stressed controls, in Group I; isolated mice subjected to the CMS protocol in Group II and aggression by physical contact in socially isolated mice subjected to the CMS protocol in Group III. In the sucrose intake test, ingestion of a 1% sucrose solution by mice in Groups II and III was significantly lower than in Group I. Furthermore, intake of this solution in Group III mice was significantly lower than in Group II mice. In the open field test, mice in Group III, showed reduced locomotor activity and reduced entry and retention time in the central zone, compared to Groups I and II mice. Moreover, the distances moved in 1 hour by Group III mice did not differ between night and morning. In the light/black box test, Groups II and III animals spent significantly less time in the light box compared to Group I animals. In the tail suspension test (TST) and forced swimming test (FST), the immobility times of Group II and Group III mice were significantly longer than in Group I mice. In addition, immobility times in the FST were significantly longer in Group III than in Group II mice.
Conclusions/Significance
These findings show that social isolation-induced aggression could potentiate anxiety and depressive -like behaviors in isolated male mice subjected to CMS.
Funding: The project was supported by the National Natural Science Foundation of China (No. 30700261 and No. 30870887) and the Ministry of Science and Technology of China (No. 2009DFA31080). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: Kenji Hashimoto is a member of Editorial Board of PLoS ONE. The other authors have declared that no competing interests exist.
