精神分裂癥患者往往有睡眠失調(diào)的問(wèn)題，過(guò)去常認(rèn)為這是精神分裂癥的副作用,，但英國(guó)一項(xiàng)最新研究認(rèn)為,，睡眠不好也有可能是精神分裂癥的誘因,。
英國(guó)布里斯托爾大學(xué)日前發(fā)布公告說(shuō)，該校研究人員對(duì)實(shí)驗(yàn)鼠進(jìn)行了觀察,，發(fā)現(xiàn)有些睡眠失調(diào)的實(shí)驗(yàn)鼠睡眠時(shí)的腦電波異常，其大腦前后部之間的腦電波不能協(xié)調(diào)一致,，特別是與記憶有關(guān)的海馬體和與做決定有關(guān)的額葉皮質(zhì)之間的信息傳輸出現(xiàn)紊亂,。腦電波的這種紊亂情況正是精神分裂癥患者常有的特征。
研究人員馬特·瓊斯說(shuō),，與睡眠失調(diào)相應(yīng)的腦電波紊亂,，為精神分裂癥提供了一種新的病理解釋?zhuān)此呤д{(diào)本身就可能是精神分裂癥的一個(gè)誘因，而不是像過(guò)去認(rèn)為的那樣只是精神分裂癥的結(jié)果,。
人們?cè)谌粘Ｉ钪幸矔?huì)感覺(jué)到,，睡眠不好會(huì)影響情緒、降低注意力,。在長(zhǎng)期缺乏睡眠的極端情況下,，還會(huì)導(dǎo)致出現(xiàn)幻覺(jué)、記憶力衰退,、思維混亂等情況,，這些也是精神分裂癥患者常出現(xiàn)的癥狀。
本次研究結(jié)果顯示了人們?cè)诿媾R精神壓力時(shí)仍需努力保持良好睡眠的重要性,。相關(guān)研究報(bào)告已發(fā)表在學(xué)術(shù)刊物《神經(jīng)元》上,。（生物谷Bioon.com）
doi: 10.1016/j.neuron.2012.09.016
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Decoupling of sleep-dependent cortical and hippocampal interactions in a neurodevelopmental model of schizophrenia
Phillips KG, Bartsch U, McCarthy AP, Edgar DM, Tricklebank MD, Wafford KA, Jones MW.
Rhythmic neural network activity patterns are defining features of sleep, but interdependencies between limbic and cortical oscillations at different frequencies and their functional roles have not been fully resolved. This is particularly important given evidence linking abnormal sleep architecture and memory consolidation in psychiatric diseases. Using EEG, local field potential (LFP), and unit recordings in rats, we show that anteroposterior propagation of neocortical slow-waves coordinates timing of hippocampal ripples and prefrontal cortical spindles during NREM sleep. This coordination is selectively disrupted in a rat neurodevelopmental model of schizophrenia: fragmented NREM sleep and impaired slow-wave propagation in the model culminate in deficient ripple-spindle coordination and disrupted spike timing, potentially as a consequence of interneuronal abnormalities reflected by reduced parvalbumin expression. These data further define the interrelationships among slow-wave, spindle, and ripple events, indicating that sleep disturbances may be associated with state-dependent decoupling of hippocampal and cortical circuits in psychiatric diseases.
