2012年12月3日 訊 /生物谷BIOON/ --近日,，刊登在國際雜志the Journals of Gerontology Series A：Biological Sciences and Medical Sciences上的兩項研究成果揭示了，維生素D或許是改善婦女認知能力的重要成分,。
飲食中較高水平維生素D的攝入和低風險的阿爾茲海默癥風險直接相關，來自明尼阿波利斯（Minneapolis）退伍軍人醫(yī)療中心的研究者指出,，在老年婦女中,，低水平的維生素D和高風險的認知損傷、認知功能下降直接相關,。
研究者Slinin對6257名社區(qū)長期居住的老年婦女進行研究揭示了,，低水平的維生素D（每毫升血液中少于10毫微克）和高風險的認知功能損傷直接相關，每毫升血液中維生素D少于20毫微克的老年婦女,，其患認知功能下降的風險明顯增加,。
另外研究者Annweieler度498名社區(qū)常住婦女進行了研究，發(fā)現(xiàn)患有阿爾茲海默癥的患者,，其攝入的維生素D水平較低,，平均每周攝入50.3微克，而患別的癡呆的患者其每周攝入63.6微克,，沒有任何癡呆的個體其每周維生素D的攝入為59.0微克,。
這些研究成果揭示了，無論是男性還是女性,，如果日常維生素D攝入不夠,，那么其患運動性限制疾病或者認知殘疾的風險將會增加。（生物谷Bioon.com）
doi:10.1093/gerona/gls107
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Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer’s Disease: A 7-Year Follow-up
Cédric Annweiler1, Yves Rolland2, Anne M Schott3, Hubert Blain4, Bruno Vellas2, François R. Herrmann5 and Olivier Beauchet1
Background. Hypovitaminosis D is associated with cognitive decline among older adults. The relationship between vitamin D intakes and cognitive decline is not well understood. Our objective was to determine whether the dietary intake of vitamin D was an independent predictor of the onset of dementia within 7 years among women aged 75 years and older. Methods. Four hundred and ninety-eight community-dwelling women (mean, 79.8 ± 3.8 years) free of vitamin D supplements from the EPIDemiology of OSteoporosis Toulouse cohort study were divided into three groups according to the onset of dementia within 7 years (ie, no dementia, Alzheimer’s disease [AD], or other dementias). Baseline vitamin D dietary intakes were estimated from self-administered food frequency questionnaire. Age, body mass index, initial cognitive performance, education level, physical activity, sun exposure, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and baseline season were considered as potential confounders. Results. Women who developed AD (n = 70) had lower baseline vitamin D intakes (mean, 50.3 ± 19.3 μg/wk) than nondemented (n = 361; mean intake = 59.0 ± 29.9 μg/wk, p = .027) or those who developed other dementias (n = 67; mean intake = 63.6 ± 38.1 μg/wk, p = .010). There was no difference between other dementias and no dementia (p = .247). Baseline vitamin D dietary intakes were associated with the onset of AD (adjusted odds ratio = 0.99 [95% confidence interval = 0.98–0.99], p = .041) but not with other dementias (p = .071). Being in the highest quintile of vitamin D dietary intakes was associated with a lower risk of AD compared with the lower 4 quintiles combined (adjusted odds ratio = 0.23 [95% confidence interval = 0.08–0.67], p = .007). Conclusions. Higher vitamin D dietary intake was associated with a lower risk of developing AD among older women.
