美國加州大學(xué)洛杉磯分校研究人員日前公布的研究報告稱,,在睡眠呼吸暫停綜合癥患者中,,女性腦部所受損傷大于男性。
在這項研究中,研究人員對比了10名新確診患有阻塞性睡眠呼吸暫停綜合癥且未接受治療的女性,、20名存在同樣情況的男性及50名健康男女的大腦狀況,。他們發(fā)現(xiàn),女性患者的大腦白質(zhì)受損更多,,其受影響的部位主要是大腦前部的扣帶束和前扣帶皮層,。這些大腦區(qū)域主要負(fù)責(zé)作決定和情緒調(diào)控,這些女性患者也因此更容易出現(xiàn)高血壓和焦慮癥狀,。
相關(guān)研究報告已發(fā)表在美國《睡眠》雜志12月刊上,。研究人員表示,他們目前還不能確定睡眠呼吸暫停綜合癥與大腦損傷之間是否存在因果關(guān)系,,其下一步計劃是揭示睡眠呼吸暫停綜合癥患者大腦發(fā)生變化的時間點(diǎn),。
阻塞性睡眠呼吸暫停綜合癥是一種常見的睡眠障礙,患者睡眠過程中氣道反復(fù)阻塞導(dǎo)致不斷出現(xiàn)呼吸暫停,,最典型的癥狀就是打鼾,。癥狀發(fā)作時,患者血液中的氧分下降,,最終導(dǎo)致體內(nèi)細(xì)胞受損,,如不接受治療,最終可能導(dǎo)致高血壓,、中風(fēng),、心臟病、糖尿病等嚴(yán)重健康問題,。(生物谷Bioon.com)
doi: 10.5665/sleep.2228
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PMID:
Sex differences in white matter alterations accompanying obstructive sleep apnea
Macey PM, Kumar R, Yan-Go FL, Woo MA, Harper RM.
STUDY OBJECTIVES: Females with obstructive sleep apnea (OSA) show different psychological and physiological symptoms from males, which may be associated with sex-related variations in neural injury occurring with the disorder. To determine whether male- or female-specific brain injury is present in OSA, we assessed influences of sex on white matter changes in the condition. DESIGN: Two-group factorial. SETTING: University medical center. PATIENTS OR PARTICIPANTS: 80 subjects total, with newly diagnosed, untreated OSA groups of 10 female (age mean ± SE: 52.6 ± 2.4 years, AHI 22.5 ± 4.1 events/h) and 20 male (age 48.9 ± 1.7, AHI 25.5 ± 2.9) patients, and 20 female (age 50.3 ± 1.7) and 30 male (age 49.2 ± 1.4) healthy control subjects. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Brain fiber integrity was assessed with fractional anisotropy (FA), a diffusion tensor imaging-derived measure. Sleep quality, daytime sleepiness, depression, and anxiety were assessed with questionnaires. We identified regions of differing injury in male versus female OSA patients by assessing brain regions with significant interaction effects of OSA and sex on FA. Areas of sex-specific, OSA-related FA reductions appeared in females relative to males, including in the bilateral cingulum bundle adjacent to the mid hippocampus, right stria terminalis near the amygdala, prefrontal and posterior-parietal white matter, corpus callosum, and left superior cerebellar peduncle. Females with OSA showed higher daytime sleepiness, anxiety and depression levels, and reduced sleep quality. CONCLUSIONS: Sex differences in white matter structural integrity appeared in OSA patients, with females more affected than males. These female-specific structural changes may contribute to or derive from neuropsychological and physiological symptom differences between sexes. CITATION: Macey PM; Kumar R; Yan-Go FL; Woo MA; Harper RM. Sex differences in white matter alterations accompanying obstructive sleep apnea