盡管在過去的10年里，產(chǎn)科和新生兒科的治療技術(shù)取得了重要進(jìn)展,，但圍產(chǎn)期缺氧缺血仍是新生兒死亡的重要原因之一。
缺氧缺血性腦病常引起運(yùn)動(dòng)障礙性腦性癱瘓,，由于缺氧缺血性腦損傷通常是不可預(yù)期的,，所以損傷后的干預(yù)顯得尤為重要。
近年來對(duì)此問題的研究主要集中在應(yīng)用神經(jīng)保護(hù)劑治療圍產(chǎn)期缺氧缺血性腦病效果的評(píng)價(jià)方面,。來自西班牙的Idoia Lara Celador所在團(tuán)隊(duì)于2013年3月第8期《中國(guó)神經(jīng)再生研究（英文版）》Neural Regen Res雜志發(fā)表的一篇文章,，“Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic- ischemic brain injury”綜述了缺氧缺血性腦病的病理損害，以及各種神經(jīng)保護(hù)手段對(duì)缺氧缺血性腦病的治療效果,，重點(diǎn)分析了內(nèi)源性大麻素系統(tǒng)作為天然的神經(jīng)保護(hù)系統(tǒng),，在缺氧缺血性腦損傷防治中所發(fā)揮的重要作用。（生物谷Bioon.com）
doi:10.3969/j.issn.1673-5374.2013.08.008
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Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic- ischemic brain injury
Lara-Celador, I.1, Goñi-de-Cerio, F.2, Antonia Alvarez1, Enrique Hilario1
One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic- ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage and finally producing cell death. Effective therapeutic treatments against this phenomenon are still unavailable because of complex molecular mechanisms underlying hypoxic-ischemic brain injury. After a thorough understanding of the mechanism underlying neural plasticity following hypoxic-ischemic brain injury, various neuroprotective therapies have been developed for alleviating brain injury and improving long-term outcomes. Among them, the endocannabinoid system emerges as a natural system of neuroprotection. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. The aim of this review is to study the use of different therapies to induce long-term therapeutic effects after hypoxic-ischemic brain injury, and analyze the important role of the endocannabinoid system as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.
