化療是腫瘤的主要治療手段之一，在取得療效的同時(shí),，還發(fā)現(xiàn)這種治療方法會引起一系列神經(jīng)系統(tǒng)副作用,，如血管并發(fā)癥,、癲癇、情緒異常,、認(rèn)知功能障礙和周圍神經(jīng)病變,。化療引起背根神經(jīng)節(jié)和背角神經(jīng)元離子通道變化,，引起繼發(fā)性損傷神經(jīng)病理痛,。盡管現(xiàn)在已開發(fā)出許多化療保護(hù)劑，但其作用效果仍不理想,?；熕幬锟梢鸷ｑR神經(jīng)發(fā)生和神經(jīng)可塑性發(fā)生變化。發(fā)表于2013年6月第17期《中國神經(jīng)再生研究（英文版）》雜志的“Neurotoxicity of cancer chemotherapy”聚集于化療藥物引發(fā)的神經(jīng)退行性變和與記憶關(guān)系最為密切的海馬功能障礙的體內(nèi)和體外研究進(jìn)展,。這將為進(jìn)一步研究化療藥物引發(fā)的神經(jīng)系統(tǒng)副作用提供幫助,，并為新型化療藥物的研發(fā)提供線索。（生物谷Bioon.com）
生物谷推薦英文摘要：
Neural Regeneration Research doi: 10.3969/j.issn.1673-5374.2013.17.009
Neurotoxicity of cancer chemotherapy
Miyoung Yang, Changjong Moon
There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.
