英國(guó)科學(xué)家在最近的胃腸病學(xué)雜志Gut上發(fā)表文章稱，對(duì)炎癥性腸病病因研究有新發(fā)現(xiàn),，IL23起關(guān)鍵作用。
炎癥性腸?。↖BD）是一種病因尚不十分清楚的慢性非特異性腸道炎癥性疾病,，包括潰瘍性結(jié)腸炎（UC）和克羅恩病(CD)。
人群遺傳學(xué)和小鼠功能學(xué)實(shí)驗(yàn)研究證實(shí),，白介素23(IL23)及其受體是炎癥性腸病(IBD)發(fā)病的關(guān)鍵因素,。McGovern教授說，IL23的一個(gè)重要作用就是引起免疫系統(tǒng)的自分泌,，產(chǎn)生大量的炎癥介質(zhì),，從而激發(fā)腸道的炎癥反應(yīng)。人群遺傳學(xué)研究發(fā)現(xiàn),，IL23基因與IBD易感性有關(guān),。
這一發(fā)現(xiàn)，揭示了IL23系統(tǒng)在IBD中的作用,，為IBD的治療提供了新途徑,。（醫(yī)學(xué)空間）
原始出處:
Gut 2007;56:1333-1336; doi:10.1136/gut.2006.115402
The IL23 axis plays a key role in the pathogenesis of IBD
Dermot McGovern1, Fiona Powrie2
1 Imperial College, London, Hammersmith Hospital Campus, Du Cane Road, London, UK
2 Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford, UK
Correspondence to:
Correspondence to:
Dermot McGovern
Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK; [email protected]
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.
Abbreviations: DC, dendritic cell; IBD, irritable bowel disease; IFN, interferon ; IL, interleukin; IL23R, interleukin 23 receptor; SNP, single-nucleotide polymorphism; TGFß, transforming growth factor ß; Th, T helper; TNF, tumour necrosis factor
Figure 1 Interleukin 23 (IL23) orchestrates intestinal inflammation via multiple pathways. Bacterial stimulation induces cytokine production by epithelial cells, dendritic cells (DCs) and macrophages (M). Interferon (IFN) and IL12 act on antigen-stimulated CD4+ T cells (Tn) to induce the differentiation of IFN-secreting T helper type 1 (Th1) cells, whereas transforming growth factor ß (TGFß) and IL6 promote Th17 cells that produce IL17 and express the IL23 receptor (IL23R). IL23 produced by activated DCs sustains the Th17 response and also activates innate cells including activated myeloid cells and NK cells (NK) to produce inflammatory cytokines including IL6, tumour necrosis factor (TNF) and IL17 that drive intestinal inflammation. IL17 stimulates cytokine production by activated macrophages and can also induce cytokine and chemokine production by endothelial cells, leading to neutrophil (N) recruiment.
