腸道蠕蟲的免疫涉及CD4+ T細胞,，但殺害或驅(qū)逐這種寄生蟲的機制目前仍不十分清楚。在10月16日的《細胞—宿主與微生物》（Cell Host & Microbe）雜志上,，McCoy等人報道,，抗體在免疫腸道蠕蟲幽門螺桿菌過程中發(fā)揮的重要作用。
幽門螺桿菌是小鼠中常見寄生蟲,，會導致慢性感染,。最新研究發(fā)現(xiàn)，正常及感染幽門螺桿菌后的老鼠身上的多克隆IgG抗體,，可以通過限制成年寄生蟲產(chǎn)卵來發(fā)揮作用,。相比之下，親和力成熟的寄生蟲特異性IgG和IgA抗體只有通過多次感染才能生成,。
這些研究結果表明,，多克隆與親和力成熟的寄生蟲特異性抗體之間在功能上有互補作用，它們分別執(zhí)行限制腸道蠕蟲繁殖與提供免疫保護的功能,。McCoy等認為,，寄生蟲引起的多克隆抗體發(fā)揮了雙重作用，即允許寄生蟲緩慢感染的同時又在限制寄生蟲的繁殖和擴散,，這很可能反映了蠕蟲寄生蟲與宿主長期協(xié)同進化的結果,。（生物谷Bioon.com）
生物谷推薦原始出處：
Cell Host & Microbe，Volume 4, Issue 4, 362-373, 16 October 2008,，Kathy D. McCoy, Nicola L. Harris
Polyclonal and Specific Antibodies Mediate Protective Immunity against Enteric Helminth Infection
Kathy D. McCoy1,3,,,Maaike Stoel3,6,Rebecca Stettler4,Patrick Merky1,Katja Fink1,Beatrice M. Senn1,Corinne Schaer4,Joanna Massacand4,Bernhard Odermatt2,Hans C. Oettgen5,Rolf M. Zinkernagel1,Nicolaas A. Bos6,Hans Hengartner1,Andrew J. Macpherson1,3,7andNicola L. Harris1,4,7,,
1 Institute of Experimental Immunology, Department of Pathology, Universit?tsspital, CH8091 Zürich, Switzerland
2 Laboratory for Special Techniques, Institute for Clinical Pathology, Universit?tsspital, CH8091 Zürich, Switzerland
3 Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada
4 Environmental Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology, CH-8952 Schlieren, Switzerland
5 Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
6 Department of Cell Biology, Section Immunology, 9713AV Groningen, The Netherlands
Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes chronic infection. Polyclonal IgG antibodies, present in naive mice and produced following Hp infection, functioned to limit egg production by adult parasites. Comparatively, affinity-matured parasite-specific IgG and IgA antibodies that developed only after multiple infections were required to prevent adult worm development. These data reveal complementary roles for polyclonal and affinity-matured parasite-specific antibodies in preventing enteric helminth infection by limiting parasite fecundity and providing immune protection against reinfection, respectively. We propose that parasite-induced polyclonal antibodies play a dual role, whereby the parasite is allowed to establish chronicity, while parasite load and spread are limited, likely reflecting the long coevolution of helminth parasites with their hosts.
