丹麥一項(xiàng)研究顯示,，銀屑病與中風(fēng)和心房顫動(dòng)有關(guān),，年紀(jì)越輕、銀屑病癥狀越嚴(yán)重的患者,，患中風(fēng)和心房顫動(dòng)幾率越大,。
顯關(guān)聯(lián)
丹麥哥本哈根大學(xué)根措夫特醫(yī)院心臟病專家奧勒·阿勒霍夫與同事分析丹麥約450萬青少年與成年人1997年至2006年間的數(shù)據(jù)。這些人中,，約3.7萬人有中度銀屑病,，2793人癥狀嚴(yán)重。
分析結(jié)果顯示,，年齡50歲以下患有中度銀屑病的人,，心房顫動(dòng)幾率比普通人多50%，缺血性中風(fēng)幾率多97%,。銀屑病癥狀嚴(yán)重的人,，心房顫動(dòng)和缺血性中風(fēng)的幾率比普通人多198%和180%。
50歲以上銀屑病患者患心房顫動(dòng)和中風(fēng)的幾率大大降低,。
心房顫動(dòng)簡(jiǎn)稱房顫,，是最常見的心率失常之一，可能引起心力衰竭和動(dòng)脈栓塞等嚴(yán)重并發(fā)癥,。缺血性中風(fēng)是指腦血栓引起的腦梗塞和腦動(dòng)脈堵塞,，通常會(huì)引發(fā)偏癱和意識(shí)障礙。
增風(fēng)險(xiǎn)
英國(guó)廣播公司28日引述研究人員的話報(bào)道：“心房顫動(dòng)和缺血性中風(fēng)的危險(xiǎn)在那些年輕且銀屑病癥狀嚴(yán)重的人中最高,。這一研究結(jié)果進(jìn)一步證明,，銀屑病患者患心血管疾病的風(fēng)險(xiǎn)更大,。”
近年來，一系列研究相繼證明銀屑病與心臟和血管問題存在關(guān)聯(lián),。阿勒霍夫說,，在人們的認(rèn)知中，“銀屑病從一種單純影響外貌的疾病成為一種系統(tǒng)疾病,，是增加心血管疾病的風(fēng)險(xiǎn)因素”,。
中風(fēng)協(xié)會(huì)研究員沙爾林·艾哈邁德說：“先前研究已經(jīng)表明，銀屑病會(huì)增加心臟病風(fēng)險(xiǎn),，這一研究顯示,，它還會(huì)增加心房顫動(dòng)和中風(fēng)風(fēng)險(xiǎn)。”
研究結(jié)果由最新一期《歐洲心臟期刊》發(fā)表,。不過艾哈邁德說,，研究結(jié)果并不意味著銀屑病一定引發(fā)房顫和中風(fēng)。
重健康
銀屑病是一種常見慢性皮膚病,，特征是在紅斑上反復(fù)出現(xiàn)多層銀白色干燥鱗屑,，又被稱為牛皮癬，是一種免疫系統(tǒng)疾病,。
正常情況下，人體皮膚細(xì)胞每三周至四周更新一次,，但是銀屑病人的免疫系統(tǒng)攻擊健康細(xì)胞,，導(dǎo)致皮膚細(xì)胞更新的速度加快到兩天至六天一次，這樣,，老舊細(xì)胞來不及從皮膚上脫落,，導(dǎo)致紅腫和多層干屑出現(xiàn)。
研究人員說,，免疫系統(tǒng)攻擊健康細(xì)胞會(huì)引發(fā)炎癥,，這種炎癥可能與中風(fēng)和心臟問題有關(guān)。
艾哈邁德建議銀屑病人定期檢查心臟,，改善生活方式,，比如戒煙、多做運(yùn)動(dòng),，從而降低罹患心臟病風(fēng)險(xiǎn),。(生物谷 Bioon.com)
doi:10.1093/eurheartj/ehr285
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Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study
Ole Ahlehoff, Gunnar H. Gislason, Casper H. J rgensen, Jesper Lindhardsen, Mette Charlot, Jonas B. Olesen, Steen Z. Abildstr m, Lone Skov, Christian Torp-Pedersen and Peter Riis Hansen
Aims Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis. Methods and results Cohort study of the entire Danish population followed from 1997 to 2006 by individual-level-linkage of nationwide prospectively recorded registers. Multivariable Poisson's regression and sensitivity analyses were used to assess the psoriasis-related risk of AF and ischaemic stroke. A total of 36 765 patients with mild psoriasis and 2793 with severe psoriasis were compared with 4 478 926 individuals, i.e. the reference population. In patients with mild psoriasis, the adjusted rate ratios (RRs) for AF were 1.50 (1.21–1.86) and 1.16 (1.08–1.24) in patients aged <50 and ≥50 years, respectively. Patients with severe psoriasis had a higher risk of AF with RRs 2.98 (1.80–4.92) in patients aged <50 years and 1.29 (1.01–1.65) in patients aged ≥50 years. Patients with psoriasis also demonstrated a disease severity-dependent increased risk of ischaemic stroke, i.e. RRs 1.97 (1.66–2.34) and 2.80 (1.81–4.34) in patients aged <50 years with mild and severe psoriasis, and RRs 1.13 (1.04–1.21) and 1.34 (1.04–1.71) in patients aged ≥50 years with mild and severe psoriasis, respectively. A range of sensitivity analyses yielded comparable results. Conclusion Psoriasis is associated with increased risk of AF and ischaemic stroke. These novel results add to a growing body of evidence, suggesting that patients with psoriasis could be considered at increased cardiovascular risk.
