日前，美研究人員在線發(fā)表了題為《Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells》研究論文,，闡明了朗格漢斯細胞是如何維持皮膚組織的免疫自穩(wěn),。該研究論文發(fā)表在國際期刊Immunity上。
正常成年人的皮膚中常駐著100-200億個記憶T細胞,，其中包括各種輔助性T細胞,、細胞毒素T細胞和調(diào)節(jié)性T細胞，它們隨時準備著與抗原發(fā)生反應(yīng)。
當(dāng)未受到外界抗原的刺激時,，表皮的朗格漢斯細胞特異性地選擇并激活皮膚中的調(diào)節(jié)性T細胞,；當(dāng)受到外界抗原的刺激時，表皮的朗格漢斯細胞限制調(diào)節(jié)性T細胞的激活,，卻特異性地激活并誘導(dǎo)記憶T細胞的增殖,。
最終，朗格漢斯細胞在皮膚中的作用得到了闡明,，即在未受外界抗原的刺激時保持機體免疫耐受,；受到外界抗原的刺激時激活記憶T細胞發(fā)揮防護作用。（生物谷 Bioon.com)
doi.org/10.1016/j.immuni.2012.03.018
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Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells
Julien Seneschal1, 2, Rachael A. Clark1, Ahmed Gehad1, Clare M. Baecher-Allan1, Thomas S. Kupper1,
1 Department of Dermatology/Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, MA 02115, USA
2 Department of Dermatology and Pediatric Dermatology/ University of Bordeaux, INSERM U1035 and CIRID UMR 5164, Bordeaux, France
Summary
Recent studies have demonstrated that the skin of a normal adult human contains 10–20 billion resident memory T cells, including various helper, cytotoxic, and regulatory T cell subsets, that are poised to respond to environmental antigens. Using only autologous human tissues, we report that both in vitro and in vivo, resting epidermal Langerhan cells (LCs) selectively and specifically induced the activation and proliferation of skin resident regulatory T (Treg) cells, a minor subset of skin resident memory T cells. In the presence of foreign pathogen, however, the same LCs activated and induced proliferation of effector memory T (Tem) cells and limited Treg cells' activation. These underappreciated properties of LCs, namely maintenance of tolerance in normal skin, and activation of protective skin resident memory T cells upon infectious challenge, help clarify the role of LCs in skin.
