7月26日,，Science雜志在線報道,，皮膚共生細菌通過調整局部T細胞的功能,，調節(jié)宿主皮膚免疫力,。
腸道共生細菌引起的保護和調節(jié)反應,，維持宿主與微生物的共生,。但是，在其他組織生活的共生菌對宿主免疫力和其他組織屏障炎癥的作用卻一直不清,。
本研究發(fā)現(xiàn),，在控制局部炎癥環(huán)境過程中，皮膚菌群發(fā)揮著自主性作用,，并可調節(jié)皮膚中T淋巴細胞的功能,。針對皮膚病原體的保護性免疫，關鍵在于皮膚菌群,，而不是腸道菌群,。此外，皮膚共生菌依賴于白細胞介素1受體的下游信號,，調整局部T細胞的功能,。
這些研究結果強調了，微生物作為一個組織區(qū)域分割化獨特功能的重要性,，并為人類了解在健康和疾病條件下,，共生菌微環(huán)境調節(jié)宿主免疫力的機制，提供了新的線索,。(生物谷bioon.com)
doi:10.1016/j.cell.2011.10.017
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Compartmentalized Control of Skin Immunity by Resident Commensals
Shruti Naik1,2,Nicolas Bouladoux1,Christoph Wilhelm1,Michael J. Molloy1,Rosalba Salcedo3,4,Wolfgang Kastenmuller5,Clayton Deming6,Mariam Quinones7,Lily Koo8,Sean Conlan6,Sean Spencer1,2,Jason A. Hall9,Amiran Dzutsev3,4,Heidi Kong10,Daniel J. Campbell11,12,Giorgio Trinchieri3,Julia A. Segre6,Yasmine Belkaid1,*
Intestinal commensal bacteria induce protective and regulatory responses that maintain host-microbial mutualism. The contribution of tissue resident commensals to immunity and inflammation at other barrier sites, however, has not been addressed. Here, we report an autonomous role for the skin microbiota in controlling the local inflammatory milieu and tuning resident T lymphocyte function. Protective immunity to a cutaneous pathogen was critically dependent on the skin but not gut microbiota. Furthermore, skin commensals tuned the function of local T cells in a manner dependent on signaling downstream of the interleukin-1 receptor. These findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization and provide insight into mechanisms of immune regulation by resident commensal niches in health and disease.
