7月27日，Immunity雜志報(bào)道,，科學(xué)家發(fā)現(xiàn)了一類新的樹突細(xì)胞可大大促進(jìn)免疫療法的研究進(jìn)展,。
樹突狀細(xì)胞（DC）介導(dǎo)，交叉呈遞在外周循環(huán)中獲得的外源性抗原,，對(duì)于發(fā)起CD8 + T細(xì)胞反應(yīng)是至關(guān)重要的,。以往研究描述了幾個(gè)在人體組織中的DC亞群，但遷徙性交叉抗原遞呈DC細(xì)胞并沒有被分離到,。它們對(duì)于機(jī)體抵抗病原體和腫瘤的免疫力,，與疫苗的相互作用和對(duì)自身組織的免疫耐受具有潛在重要性。
本研究發(fā)現(xiàn),， 高表達(dá)CD141（CD141hi）DC細(xì)胞存在于人類間質(zhì)真皮,，肝，肺,。此外,，這群DC細(xì)胞有別于大部分CD1c+和CD14+組織DC細(xì)胞，在交叉呈遞可溶性抗原方面性能更為優(yōu)越,。皮膚CD141hiDC細(xì)胞與血液CD141+DC細(xì)胞密切相關(guān),，而遷徙性CD141hiDC細(xì)胞被發(fā)現(xiàn)與皮膚引流淋巴結(jié)DC細(xì)胞之中。物種間比較轉(zhuǎn)錄組分析表明,，組織中的DC細(xì)胞亞群,，在人類和小鼠之間在進(jìn)化上是保守的。
這些研究為設(shè)計(jì)有針對(duì)性的免疫療法,，促進(jìn)將小鼠DC細(xì)胞生物學(xué)的研究成果應(yīng)用于人類打下了良好的基礎(chǔ),。（生物谷bioon.com）
doi:10.1016/j.cell.2011.10.017
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Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells
Muzlifah Haniffa, Amanda Shin, Venetia Bigley, Naomi McGovern, Pearline Teo, Peter See, Pavandip Singh Wasan, Xiao-Nong Wang, Frano Malinarich, Benoit Malleret, Anis Larbi, Pearlie Tan, Helen Zhao, Michael Poidinger, Sarah Pagan, Sharon Cookson, Rachel Dickinson, Ian Dimmick, Ruth F. Jarrett, Laurent Renia, John Tam, Colin Song, John Connolly, Jerry K.Y. Chan, Adam Gehring, Antonio Bertoletti, Matthew Collin, Florent Ginhoux
Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8+ T cell responses. Several DC subsets are described in human tissues but migratory cross-presenting DCs have not been isolated, despite their potential importance in immunity to pathogens, vaccines, and tumors and tolerance to self. Here, we identified a CD141hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c+ and CD14+ tissue DCs and superior at cross-presenting soluble antigens. Cutaneous CD141hi DCs were closely related to blood CD141+ DCs, and migratory counterparts were found among skin-draining lymph node DCs. Comparative transcriptomic analysis with mouse showed tissue DC subsets to be conserved between species and permitted close alignment of human and mouse DC subsets. These studies inform the rational design of targeted immunotherapies and facilitate translation of mouse functional DC biology to the human setting.
