研究人員研發(fā)出了一種人工合成的分子,，它可讓外來顆粒逃避免疫系統(tǒng)的檢測,。這種合成肽可被用來改善藥物向腫瘤的輸送并增進(jìn)醫(yī)學(xué)成像技術(shù)。目前的藥物輸送及成像策略受到了免疫系統(tǒng)快速識別并清除外來顆粒能力的阻礙,。所謂的“自我”細(xì)胞通過被一種叫做CD47的膜蛋白標(biāo)記而受到不被清除的保護(hù),。通過使用計(jì)算設(shè)計(jì)技術(shù)，Pia Rodriguez及其同事研發(fā)出了一種合成的基于人類CD47的肽,。當(dāng)研究人員將標(biāo)記了該合成分子的納米顆粒注射到小鼠體內(nèi)時(shí),，該合成肽阻止了被稱作吞噬細(xì)胞的白血球吞噬該納米顆粒。該結(jié)果提示,，這些合成肽是有效的逃避免疫系統(tǒng)的物質(zhì),，它可能在多種應(yīng)用中起到作用。（生物谷Bioon.com）
DOI: 10.1126/science.1229568
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PMID:
Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
P.L. Rodriguez; T. Harada; D.A. Christian; D.A. Pantano; R.K. Tsai; D.E. Discher
Foreign particles and cells are cleared from the body by phagocytes that must also recognize and avoid clearance of "self" cells. The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a. Minimal "Self" peptides were computationally designed from human CD47 and then synthesized and attached to virus-size particles for intravenous injection into mice that express a CD172a variant compatible with hCD47. Self peptides delay macrophage-mediated clearance of nanoparticles, which promotes persistent circulation that enhances dye and drug delivery to tumors. Self-peptide affinity for CD172a is near the optimum measured for human CD172a variants, and Self peptide also potently inhibits nanoparticle uptake mediated by the contractile cytoskeleton. The reductionist approach reveals the importance of human Self peptides and their utility in enhancing drug delivery and imaging.
