信息素和“犁鼻器”對它們的檢測已知主管小鼠的社會(huì)行為，但很少有化學(xué)信號(hào)被與特定行為反應(yīng)聯(lián)系起來?，F(xiàn)在,，Haga等人發(fā)現(xiàn)，雄性眼淚中分泌的ESP1肽使得雌性愿意接受交配,，并且還識(shí)別出了它的“犁鼻器”受體(V2Rp5)及在行為反應(yīng)中被激發(fā)的性別特異性神經(jīng)通道,。這樣的“標(biāo)記線”邏輯是否能夠延伸到其他哺乳動(dòng)物生殖行為的調(diào)控仍然不清楚。(生物谷Bioon.net)
生物谷推薦原文出處：
Nature doi:10.1038/nature09142
The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
Sachiko Haga,Tatsuya Hattori,Toru Sato,Koji Sato,Soichiro Matsuda,Reiko Kobayakawa,Hitoshi Sakano,Yoshihiro Yoshihara,Takefumi Kikusui& Kazushige Touhara
Various social behaviours in mice are regulated by chemical signals called pheromones that act through the vomeronasal system1, 2, 3. Exocrine gland-secreting peptide 1 (ESP1) is a 7-kDa peptide that is released into male tear fluids and stimulates vomeronasal sensory neurons in female mice4. Here, we describe the molecular and neural mechanisms that are involved in the decoding of ESP1 signals in the vomeronasal system, which leads to behavioural output in female mice. ESP1 is recognized by a specific vomeronasal receptor, V2Rp5, and the ligand–receptor interaction results in sex-specific signal transmission to the amygdaloid and hypothalamic nuclei via the accessory olfactory bulb. Consequently, ESP1 enhances female sexual receptive behaviour upon male mounting (lordosis), allowing successful copulation. In V2Rp5-deficient mice, ESP1 induces neither neural activation nor sexual behaviour. These findings show that ESP1 is a crucial male pheromone that regulates female reproductive behaviour through a specific receptor in the mouse vomeronasal system.
