荷蘭一項(xiàng)研究顯示，紅酒中的“神奇物質(zhì)”白藜蘆醇能減少肥胖對(duì)身體的負(fù)面影響,，降低肥胖人士年老后罹患疾病的風(fēng)險(xiǎn)。
研究報(bào)告由最新一期美國(guó)《細(xì)胞－代謝》月刊發(fā)表,。
荷蘭馬斯特里赫特大學(xué)研究人員給11名肥胖男性每天注射含150毫克白藜蘆醇的針劑,。一個(gè)月后，這些人的收縮壓降低5毫米汞柱,，新陳代謝速度放緩,，身體能量消耗減少2%至4%,。
研究人員說,，新陳代謝速度放緩意味著人不需要像以前吃得那么多，仍可以維持身體正常運(yùn)轉(zhuǎn),。這樣可減少肥胖人士肝臟部位聚積的脂肪,，降低血壓和血糖。
英國(guó)媒體11月1日援引研究負(fù)責(zé)人馬斯特里赫特大學(xué)教授施拉烏文的話報(bào)道,，白藜蘆醇對(duì)肥胖人士的作用微小卻重要,，“在我看來，它們（白藜蘆醇）的作用非常穩(wěn)定,，讓許多參數(shù)發(fā)生細(xì)微變化”,。
“我們只注射30天，還不清楚長(zhǎng)時(shí)間注射會(huì)產(chǎn)生什么結(jié)果,，”他說,，“新陳代謝變化需要一段時(shí)間才能顯現(xiàn)出來，因此,，（白藜蘆醇）給身體帶來的影響可能更明顯”,。
白藜蘆醇存在于紅酒、葡萄,、桑葚和花生中,。不過，要想通過飲用紅酒獲得實(shí)驗(yàn)中11名肥胖者的效果,，每天必須喝下13瓶酒才夠,，這樣做顯然弊大于利,。（生物谷 Bioon.com）
doi:10.1016/j.cmet.2011.10.002
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Silvie Timmers, Ellen Konings, Lena Bilet, Riekelt H. Houtkooper, Tineke van de Weijer, Gijs H. Goossens, Joris Hoeks, Sophie van der Krieken, Dongryeol Ryu, Sander Kersten, Esther Moonen-Kornips, Matthijs K.C. Hesselink, Iris Kunz, Vera B. Schrauwen-Hinderling, Ellen E. Blaak, Johan Auwerx, Patrick Schrauwen
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
