紐約醫(yī)學(xué)院心血管研究所主任Piero Anversa醫(yī)學(xué)博士再次證明,，心臟有自己獨(dú)特的用來心臟病發(fā)作后再生心肌組織的成體干細(xì)胞。這篇研究發(fā)表在9月19日期的《細(xì)胞》雜志上,，建立在幾周前在《美國(guó)科學(xué)院院刊》(PNAS)上發(fā)表的一篇研究之上,。
《細(xì)胞》上的這篇研究是在Anversa博士的實(shí)驗(yàn)室中進(jìn)行的，由Anversa博士,、Bernardo Nadal-Ginard博士,、Annarosa Leri醫(yī)學(xué)博士和Jan Kajstura博士領(lǐng)導(dǎo)的研究小組完成。“直到最近,，心臟生物學(xué)的理論還普遍認(rèn)為成熟哺乳動(dòng)物的心臟是沒有再生能力的后有絲分裂器官,。也就是說從剛出生到成年到衰老，心臟的心肌細(xì)胞數(shù)量相對(duì)穩(wěn)定但又還面減少,。但越來越多的證據(jù)向這個(gè)觀點(diǎn)提出了挑戰(zhàn),。
Anversa博士在心力衰竭研究中發(fā)現(xiàn)了大量證據(jù)證明心臟具有自我修復(fù)能力，從而駁斥了干細(xì)胞只能從血液,、皮膚,、中樞神經(jīng)系統(tǒng)、肝臟,、胃腸道和骨骼肌等成熟組織中獲得的觀點(diǎn),。在《細(xì)胞》的這篇研究中，Anversa和他的同事使用了分離自成年大鼠心臟的特殊細(xì)胞,，這些細(xì)胞都有心臟祖細(xì)胞的性質(zhì),。他們將富含這些心臟祖細(xì)胞的混合物導(dǎo)入肌肉萎縮的心臟，結(jié)果心臟產(chǎn)生了在結(jié)構(gòu)和功能上夠能勝任的新心肌細(xì)胞以及平滑肌細(xì)胞和內(nèi)皮細(xì)胞,。
“我們已經(jīng)識(shí)別出這些干細(xì)胞存在于何處,，正在想辦法使它們遷移到心臟受損部位,。到時(shí)我們會(huì)將I期臨床試驗(yàn)的草案呈交給FDA審批,。”Anversa博士表示
參考：
Hope for a Broken Heart?
Leslie A. Leinwand
[Summary] [Full Text] [PDF]
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio P. Beltrami, Laura Barlucchi, Daniele Torella, Mathue Baker, Federica Limana, Stefano Chimenti, Hideko Kasahara, Marcello Rota, Ezio Musso, Konrad Urbanek, Annarosa Leri, Jan Kajstura, Bernardo Nadal-Ginard, and Piero Anversa
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