根據(jù)美國(guó)牙周病學(xué)會(huì)最新發(fā)表在《牙周病學(xué)》雜志中的研究結(jié)果顯示,，口腔中存在的一種特殊細(xì)菌與牙周袋中的細(xì)菌成分可解釋牙周病和急性冠狀動(dòng)脈綜合征（ACS）之間的相關(guān)性,。
研究發(fā)現(xiàn),，ACS患者群體的口腔細(xì)菌如streptococci spp、P. gingivalis,、T. forsythia和T. denticola等的數(shù)量提高了兩倍多，研究結(jié)果顯示了這些細(xì)菌與牙周炎和ACS的感染病原學(xué)中有相似之處,。
該研究結(jié)果可能解釋為什么提高細(xì)菌含量和結(jié)合特殊病原物可能同時(shí)與牙周病及ACS的發(fā)生相關(guān),。同時(shí)，研究人員也發(fā)現(xiàn)牙周病細(xì)菌導(dǎo)致炎癥應(yīng)答,，并增加白細(xì)胞數(shù)量及其對(duì)C反應(yīng)蛋白水平的高靈敏度,，這些因子都是先前研究發(fā)現(xiàn)與心臟病相關(guān)的。
此外,，研究也發(fā)現(xiàn)牙槽骨丟失的增加能明顯提高ACS風(fēng)險(xiǎn)系數(shù),。77％的ACS群體和42％對(duì)照群體的受試者有明顯的牙周炎跡象。與非ACS群體相比,，ACS群體中的骨質(zhì)丟失增加導(dǎo)致的后果更為嚴(yán)重,。
患者口腔細(xì)菌含量較高的另一個(gè)原因可能歸咎于易受傳染性和缺乏足夠的宿主產(chǎn)生炎癥應(yīng)答，其中可能包括其它的系統(tǒng)血管影響導(dǎo)致了ACS發(fā)病,。
盡管該研究與先前研究結(jié)果一致,，目前尚需進(jìn)一步研究來確定減少特定細(xì)菌數(shù)量在降低ACS風(fēng)險(xiǎn)性中的作用。同時(shí),，該數(shù)據(jù)也強(qiáng)調(diào)了常規(guī)牙周病與家庭牙科護(hù)理的重要性,。
英文原文：
Periodontal bacteria may be linked to acute coronary syndrome (ACS)
By American Academy of Periodontology, The presence of specific bacteria and combinations of bacteria in periodontal pockets might be an explanation for the relationship between periodontal disease and acute coronary syndrome (ACS), according to a new study published in the Journal of Periodontology.
The amount of oral bacteria was two times higher in the ACS group for the combination of the bacteria streptococci spp, P. gingivalis, T. forsythia and T. denticola. Specifically, the findings suggest that T. denticola, T. forsythia and streptococci spp are bacteria in a shared infectious etiology for periodontitis and ACS.
"This might be one of several explanations as to why elevated bacteria and the combination of specific pathogens in periodontal pockets can be linked to a history of ACS," said Stefan Renvert, DDS, PhD and Department of Health Sciences, Kristianstad University. "We also found that the amount of periodontal bacteria results in an inflammatory response that elevates the white blood cell counts and high sensitivity C-reactive protein levels, which has also been linked in past studies to heart disease."
It was also found that the extent of alveolar bone loss was significantly greater among subjects with ACS. Seventy-seven percent of the participants in the ACS group and 42 percent in the control group demonstrated evidence of periodontitis. The extent of bone loss was more severe in the ACS group than in the non-ACS group.
Another reason people diagnosed with ACS may have higher oral bacteria could be due to their infectious susceptibility and lack of an adequate host inflammatory response, which may induce other systemic vascular effects participating in the onset of ACS.
"Although this study supports past findings, further research is needed to evaluate the effects of reducing specific bacteria such as T. forsythia and T. denticola on reducing the risk for ACS," said Kenneth A. Krebs, DMD and AAP president. "This data highlights the importance of routine periodontal examinations and at-home dental care."
