抑癌基因的負轉(zhuǎn)錄調(diào)控

The Negatively Transcriptional Regulation of the Tumor Suppressor Genes

馬利偉　張宗玉　童坦君　

摘　要：抑癌基因在正常細胞中適度表達,抑制細胞永生及轉(zhuǎn)化,其轉(zhuǎn)錄下調(diào)見于某些腫瘤,而在衰老細胞中常見表達上調(diào)或活性增強.抑癌基因INK4a/ARF,、p53和p21Cip1的表達及其負調(diào)控與腫瘤及細胞衰老的關(guān)系十分密切.

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