抑癌基因的負(fù)轉(zhuǎn)錄調(diào)控

The Negatively Transcriptional Regulation of the Tumor Suppressor Genes

馬利偉　張宗玉　童坦君　

摘　要：抑癌基因在正常細(xì)胞中適度表達(dá),抑制細(xì)胞永生及轉(zhuǎn)化,其轉(zhuǎn)錄下調(diào)見于某些腫瘤,而在衰老細(xì)胞中常見表達(dá)上調(diào)或活性增強(qiáng).抑癌基因INK4a/ARF、p53和p21Cip1的表達(dá)及其負(fù)調(diào)控與腫瘤及細(xì)胞衰老的關(guān)系十分密切.

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