?據(jù)報(bào)道,，美國研究人員一種新的檢測血液中腫瘤抗體的方法可能會(huì)在成為發(fā)現(xiàn)肺癌的新方法,，這種方法能夠在X射線和CT檢查發(fā)現(xiàn)肺癌之前檢測到肺癌的發(fā)生。研究人員稱,，通過檢測患者血液標(biāo)本能夠在患者被確診前數(shù)年預(yù)測非小細(xì)胞肺癌的發(fā)生,。如果這種檢測方法的可靠性能夠被證實(shí)的話，這種方法將成為繼PSA檢測后第一個(gè)通過血液篩選癌癥的方法,。
??肯塔基州立大學(xué)Li Zhong發(fā)表在《胸部腫瘤雜志》的文章稱,，試驗(yàn)的結(jié)果表明與復(fù)雜的篩選策略聯(lián)合應(yīng)用，通過抗體檢測可以早期預(yù)測癌癥的發(fā)生,。研究人員通過對(duì)人群進(jìn)行檢測,，以篩選出可能患肺癌的對(duì)象，從而對(duì)這種方法進(jìn)行評(píng)價(jià),。事實(shí)表明,，這種方法正確預(yù)測了90%的病例，并且假陽性率很低,。研究人員在肺癌患者被確診為肺癌前數(shù)年采集了患者血樣并進(jìn)行檢測,。被檢測的18個(gè)患者在一年、兩年,、三年,、四年后陸續(xù)被確診為肺癌。
??Zhong說：“通過兩次這種血液檢測,，肺癌可以在能夠被放射檢測手段檢測到之前的3-5年就被預(yù)測,。”
英文原文：
Blood test may find early lung cancer: US study
WASHINGTON (Reuters) - A blood test that looks for patterns of antibody responses to tumors may provide a way to detect lung cancer long before an X-ray or CT scan could, U.S. researchers reported on Friday.
The test correctly predicted non-small-cell lung cancer in blood samples taken from patients years before they were actually diagnosed with lung cancer, the researchers reported.
If the test's reliability can be confirmed, it might become the first new blood screen for any cancer since the PSA test. The test is licensed to Rockville, Maryland-based 20/20 GeneSystems Inc.
"These data suggest antibody profiling could be a powerful tool for early detection when incorporated into a comprehensive screening strategy," Li Zhong and colleagues at the University of Kentucky write in their report, published in the Journal of Thoracic Oncology.
When they the researchers evaluated the test in people who were being treated for lung cancer, it correctly identified 90 percent of cases, and with very few false positives in samples taken from people who did not have lung cancer.
The researchers tested blood samples taken from some of the lung cancer patients years before they were diagnosed. The test found cancer in four out of seven samples taken a year before diagnoses, and in all 18 samples taken two, three and four years earlier.
"Based on doubling times, a lung cancer can be present three to five years before reaching the conventional size limits of radiographic detection," Zhong's team points out.
Copyright © 2006 Reuters Limited. All rights reserved.
Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.
