生物谷報道：朊病毒越來越被發(fā)現(xiàn)具有多種特殊的生理和病理功能,，而且不僅僅是在神經(jīng)系統(tǒng)中發(fā)揮作用,。最新一期FASEB J雜志報道了中國第四軍醫(yī)大學樊代明教授最新研究成果：朊病毒能促進胃腸癌癥的侵襲和轉(zhuǎn)移！這一研究首次提出朊病毒在腫瘤中的扮演的角色,。同時進一步發(fā)現(xiàn)MEK信號,，以及其下游的MMP11在這一過程參與了重要角色。
原始出處：
Yanglin Pan, Lina Zhao, Jie Liang, Jie Liu, Yongquan Shi, Na Liu, Guoyun Zhang, Haifeng Jin, Juan Gao, Huahong Xie, Jun Wang, Zhiguo Liu, and Daiming Fan
Cellular prion protein promotes invasion and metastasis of gastric cancer
FASEB J. 2006 20: 1886-1888. Published in Advance July 28, 2006, 10.1096/fj.06-6138fje [Abstract] [Full Text] [PDF] [Summary]
英文摘要：
Cellular prion protein (PrPc) is a glycosylphosphatidylinositol (GPI) -anchored membrane protein that is highly conserved in mammalian species. PrPc has the characteristics of adhesive molecules and is thought to play a role in cell adhesion and membrane signaling. Here we investigated the possible role of PrPc in the process of invasiveness and metastasis in gastric cancers. PrPc was found to be highly expressed in metastatic gastric cancers compared to nonmetastatic ones by immunohistochemical staining. PrPc significantly promoted the adhesive, invasive, and in vivo metastatic abilities of gastric cancer cell lines SGC7901 and MKN45. PrPc also increased promoter activity and the expression of MMP11 by activating phosphorylated ErK1/2 in gastric cancer cells. MEK inhibitor PD98059 and MMP11 antibody (Ab) significantly inhibited in vitro invasive and in vivo metastatic abilities induced by PrPc. N-terminal fragment (amino acid 24–90) was suggested to be an indispensable region for signal transduction and invasion-promoting function of PrPc. Taken together, the present work revealed a novel function of PrPc that the existence of N-terminal region of PrPc could promote the invasive and metastatic abilities of gastric cancer cells at least partially through activation of MEK/ERK pathway and consequent transactivation of MMP11.—Pan, Y., Zhao, L., Liang, J., Liu, J., Shi, Y., Liu, N., Zhang, G., Jin, H., Gao, J., Xie, H., Wang, J., Liu, Z., Fan, D. Cellular prion protein promotes invasion and metastasis of gastric cancer.
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