生物谷報(bào)道：12月26日,，路透通訊社健康版報(bào)道,，妊娠早期循環(huán)中胰島素樣生長因子-1水平的升高可能會(huì)造成其得乳腺癌的風(fēng)險(xiǎn)增加，美國和瑞典研究者在12月份的《癌癥流行病學(xué),，生物標(biāo)記和預(yù)防》中這樣報(bào)道,。
紐約大學(xué)醫(yī)學(xué)院的Annekatrin博士及其同事指出，盡管有大量的報(bào)道,，但是IGF-1和乳腺癌的聯(lián)系仍不明確,。她和她的同事提出這樣的假說：出現(xiàn)高IGF-1水平的妊娠早期，會(huì)有一段以乳腺細(xì)胞強(qiáng)烈增殖為特點(diǎn)的時(shí)期,，可能會(huì)增加乳腺惡變的風(fēng)險(xiǎn),。為了進(jìn)一步調(diào)查，研究者組織了一項(xiàng)包括212項(xiàng)病例及369項(xiàng)對(duì)照的研究,。受試者婦女有部分是正在產(chǎn)科醫(yī)院中生了單胞胎并在妊娠早期留有血樣的產(chǎn)婦,。乳腺癌的風(fēng)險(xiǎn)隨著IGF-1水平的升高而增加，水平最高組與最低組之比為1.7,。這種聯(lián)系在初產(chǎn)婦組中（比率為2.2）比其他組中（比率為1.4）較強(qiáng),。而且，在有最高IGF-1水平的組中乳腺癌的風(fēng)險(xiǎn)隨年齡增加而減小,。比如,，在年齡小于28歲的比率為2.5，而在年齡大于33歲的比率則為1.2,。那些觀察到乳腺癌的風(fēng)險(xiǎn)與IGF-2的水平無關(guān)的研究者們指出,，他們正在設(shè)計(jì)一項(xiàng)更大的研究，其結(jié)果將在統(tǒng)計(jì)學(xué)上更加明確年齡在乳腺癌與IGF-1水平關(guān)系中的效應(yīng),。
原文出處：
Insulin-Like Growth Factor May Be Tied to Breast Cancer
NEW YORK (Reuters Health) Dec 26 - Elevated levels of circulating insulin-like growth factor (IGF)-1 early in pregnancy appear to be associated with an increased risk of the development of breast cancer, US and Swedish researchers report in the December issue of Cancer Epidemiology, Biomarkers and Prevention.
Dr. Annekatrin Lukanova of New York University School of Medicine and colleagues note that despite numerous reports, the association of IGF-1 with breast cancer is unclear. She and her colleagues hypothesized that exposure to high IGF-1 in early pregnancy, "a period characterized by intense cell proliferation in the breasts," might increase the risk of breast malignancy.
To investigate further, the researchers conducted a study of 212 cases and 369 controls. The women were part of an ongoing maternity cohort who delivered singleton babies and had given blood samples early in pregnancy.
Breast cancer risk increased with increasing IGF-1 levels. For those with the highest levels compared with the lowest levels, the odds ratio was 1.7. The association was stronger in primiparas (odds ratio, 2.2) than in others (odds ratio, 1.4).
In addition, the risk in those with the highest IGF-1 levels appears to decrease with increasing age. For example, the odds ratio was 2.5 in those under the age of 28 years. The corresponding value was 1.2, in women over the age of 33 years.
The researchers, who observe that there was no association between cancer risk and levels of IGF-2, note that they are now planning a much larger study "which will have adequate statistical power to address the effect of age on the association of breast cancer with circulating IGF-1."
Cancer Epidemiol Biomarkers Prev 2006;15:2489-2493.
