生物谷報道：最近,，匹斯堡和美國的研究人員指出抗逆轉錄病毒的藥物用于避免HIV從母體傳染給孩子,這種藥物可能引起嬰兒基因損害,增加嬰兒患癌癥的風險.
兩個新研究刊登在最新的環(huán)境與分子期刊上,報道在老鼠體內AZT(一種抗逆轉錄病毒的藥物)經胎盤傳遞給胎兒有引起癌癥的效應,并且發(fā)現(xiàn)腫瘤的生長速度增加了,也有癌癥基因的改變,這些在人體癌癥時常發(fā)生."雖然這些數(shù)據(jù)暗示人類兒童經胎盤被傳遞給了AZT的長期健康是不確定的,這些兒童在中老年時患癌癥風險的增加這個可能性是高度值得相信的"根據(jù)研究人員報道."積累的遺傳突變數(shù)據(jù)指出嬰兒經胎盤被傳遞給了AZT,隨著他們年齡的增長可能會提高患癌癥的風險",研究者在陳述中指出.
原文出處：
Anti-HIV Drug May Increase 'Cancer Risk'
April 7, 2007 1:15 p.m. EST
Som Patidar - All Headline News Staff Writer
Pittsburgh, PA (AHN) - American scientists say antiretroviral drugs, which are used to prevent HIV transmission from mother to child, may cause genetic damage in infants that may increase their risk of developing cancer.
Two new studies published in the latest issue of Environment and Molecular Mutagenesis suggest that there are cancer-causing effects of transplacental exposure to AZT (an antiretroviral drug) in mice and rats and found increased rates of tumors and tumors with gene changes that frequently occur in human cancer.
"Although the implications of these findings for the long-term health of human children exposed transplacentally to AZT are uncertain, the possibility of increased cancer risk for a subset of these children in mid and late adulthood appears highly plausible," according to the researchers.
"The cumulative mutagenesis data suggest that infants exposed transplacentally to AZT may be at increased risk for cancer as they age," researchers said in a statement.
