生物谷報(bào)道：美國(guó)康奈爾大學(xué)的最新研究,，蘋果皮具有良好的抗癌防癌功效。,，每天吃一個(gè)蘋果的果皮可達(dá)到預(yù)防癌癥的效果,。研究的主要負(fù)責(zé)人華裔研究人員劉瑞海（Rui Hai Liu,，音譯）和同事發(fā)現(xiàn)蘋果中幾種化合物具有抗人類肝癌、結(jié)腸癌和乳腺癌細(xì)胞增殖的活性,。這項(xiàng)研究的結(jié)果公布在本月的Journal of Agricultural and Food Chemistry的網(wǎng)絡(luò)版上,。
康奈爾之前的研究發(fā)現(xiàn)，實(shí)驗(yàn)室中,，蘋果不但能抵御癌細(xì)胞,，而且還能減少大鼠乳腺腫瘤的數(shù)量和尺寸?？的螤柕难芯咳藛T推測(cè),，三萜系化合物可以起到更多的抗癌功能。
劉博士指出,，蘋果中的一些化合物具有強(qiáng)大的抗癌功能,，能對(duì)付不同類型的癌細(xì)胞系，值得進(jìn)一步研究,。
通過與康奈爾博士后何祥久（Xiangjiu He,，音譯）合作，劉副教授分析了230磅的紅蘋果皮,，并分離出了一些化合物,。在確定了皮中的這些有潛力的化合物的結(jié)構(gòu)后，研究人員又在實(shí)驗(yàn)室中檢測(cè)了這些純化合物的抗癌細(xì)胞活性,。研究人員表示,，如果每天吃5到12個(gè)水果何蔬菜將能降低慢性疾病的風(fēng)險(xiǎn)。
大家都知道有一句英語(yǔ)諺語(yǔ)：一天一個(gè)蘋果,，醫(yī)生遠(yuǎn)離我（An apple a day keeps the doctor away）,。不過，科學(xué)家的最新研究讓這句話有了一個(gè)更精確的版本：一天一條蘋果皮,，癌癥不會(huì)來(lái)找你（An apple peel a day might keep cancer at bay）,。蘋果皮中的三萜化合物對(duì)人類肝癌、乳腺癌和結(jié)腸癌細(xì)胞具有潛在的抗增殖活性,。同時(shí),，這些化合物也能夠部分解釋“一天一個(gè)蘋果，病痛遠(yuǎn)離我”的原因,。
所以,，在保證洗干凈的前提下，蘋果還是連皮吃吧,。
原始出處:
J. Agric. Food Chem., 55 (11), 4366 -4370, 2007. 10.1021/jf063563o S0021-8561(06)03563-1
Web Release Date: May 8, 2007 Copyright © 2007 American Chemical Society
Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity
Xiangjiu He and Rui Hai Liu*
Department of Food Science and Institute of Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14853
Received for review December 8, 2006. Revised manuscript received March 26, 2007. Accepted March 27, 2007. This work was supported in part by No. 06A127 from the American Institute for Cancer Research and the Ngan Foundation.
Abstract:
Bioactivity-guided fractionation of apple peels was used to determine the chemical identity of bioactive constituents. Thirteen triterpenoids were isolated, and their chemical structures were identified. Antiproliferative activities of the triterpenoids against human HepG2 liver cancer cells, MCF-7 breast cancer cells, and Caco-2 colon cancer cells were evaluated. Most of the triterpenoids showed high potential anticancer activities against the three human cancer cell lines. Among the compounds isolated, 2-hydroxyursolic acid, 2-hydroxy-3-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3-trans-p-coumaroyloxy-2-hydroxyolean-12-en-28-oic acid showed higher antiproliferative activity toward HepG2 cancer cells. Ursolic acid, 2-hydroxyursolic acid, and 3-trans-p-coumaroyloxy-2-hydroxyolean-12-en-28-oic acid exhibited higher antiproliferative activity against MCF-7 cancer cells. All triterpenoids tested showed antiproliferative activity against Caco-2 cancer cells, especially 2-hydroxyursolic acid, maslinic acid, 2-hydroxy-3-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3-trans-p-coumaroyloxy-2-hydroxyolean-12-en-28-oic acid, which displayed much higher antiproliferative activities. These results showed the triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for the anticancer activities of whole apples.
Keywords: Apple; apple peels; phytochemicals; phenolics; triterpenoids; breast cancer; antiproliferative activities; MCF-7 cells; cancer cells
