p53蛋白及其調(diào)控因子ARF的腫瘤抑制活性，基于它們?cè)谔綔y(cè)和消除細(xì)胞損傷中所起作用。同癌癥一樣，衰老也是與細(xì)胞損傷的積累有關(guān),。從這個(gè)前提出發(fā)，Matheu等發(fā)現(xiàn),，p53 和Arf水平較高,、但卻能正常調(diào)控的小鼠不僅對(duì)癌癥有抵抗力，而且壽命也比正常小鼠更長(zhǎng),，盡管有癌癥所產(chǎn)生的影響,。讓人驚異的是，衰老的各種不同生物和分子標(biāo)記都表明,，這些小鼠能夠更長(zhǎng)時(shí)間保持年輕,。提升內(nèi)生Arf/p53活性似乎能產(chǎn)生一種抗氧化效應(yīng)，該效應(yīng)不僅抑制癌癥,，而且延緩衰老,。 該研究成果發(fā)表在最新一期的《自然》雜志上,。
原文出處：
Nature Volume 448 Number 7151(19 July 2007)
Delayed ageing through damage protection by the Arf/p53 pathway p375
Ander Matheu, Antonio Maraver, Peter Klatt, Ignacio Flores, Isabel Garcia-Cao, Consuelo Borras, Juana M. Flores, Jose Viña, Maria A. Blasco & Manuel Serrano
doi:10.1038/nature05949
First paragraph | Full Text | PDF (338K) | Supplementary information
See also: Editor's summary
相關(guān)基因：
TP53
Official Symbol TP53 and Name: tumor protein p53 (Li-Fraumeni syndrome) [Homo sapiens]
Other Aliases: LFS1, TRP53, p53
Other Designations: p53 tumor suppressor; tumor protein p53
Chromosome: 17; Location: 17p13.1
Annotation: Chromosome 17, NC_000017.9 (7512464..7531642, complement)
MIM: 191170
GeneID: 7157
作者簡(jiǎn)介：
Manuel Serrano
Publications
Here is my classified list of publications:
Compilation Garbage Collection Programming Environment Programming Languages Ubiquitous Programming
They may also be accessed in one single page.
Open your source
I contribute to make free softwares available. I'm in charge of the following ones: Bigloo (the optimizing Scheme compiler) Hop (A language for programming the web 2.0) Biglook (the Bigloo graphical toolkit) Scribe (a functional markup programming language) Skribe (a functional markup programming language) Flyspell (On-the-fly Emacs spell checker).
In addition to the ones I implement, I exclusively use free softwares. Amongst these 99% are open source. Here is a selection of the ones I was the most frequently:
All my computers run GNU/Linux. I have successively use the RedHat distribution, Mandrake, then Debian. After two years spent with Gentoo. Gentoo was great in the first place but unfortunately it has became too instable and I have had to drop it. I now use the Arch distribution. It looks like very nice. Updates go smoothly and it is possible to update from binary packages or from the sources. I edit every things with Emacs. I compile my C and C++ programs with Gcc (yes, I still prefer gcc-2.95 to gcc-3.xxx). My window manager is a patched version of Pekwm. It is light (the running process occupies less than 4MB) and fast. The patch (applicable to the version 0.1.3) fixes a nasty bug of window focus and a incompatibility with Emacs focus/unfocus operations. I use pekwm in conjunction with a thin toolbar. I read my mails with a patched version of Sylpheed Claws. The patch due, to Erick Gallesio, enables to compose and post the mails with Emacs. I synchronize the disks of my computers with Unison. I manages my versions with Prcs. Unfortunately, Prcs is now difficult to compile with the recent versions of Gcc (Prcs is implemented in C++). Someone at Debian has released some patches for compiling Prcs. I have used this patches to implement a Gentoo ebuild package. I compose my slides with Skribe and I visualize them with Advi. I browse the web with Mozilla but, as much as possible, I visualize local HTML files with Dillo. When it happens that I have to read non-ascii texts, before anything else, I give a try to Abiword.
