生物谷報(bào)道：人類染色體8q24的突變可引發(fā)前列腺癌的發(fā)病風(fēng)險(xiǎn)。最近，研究人員證實(shí)了結(jié)腸直腸癌同樣受到該類突變的調(diào)節(jié),。該研究結(jié)果發(fā)表在最新一期的《自然遺傳學(xué)》雜志上。
研究人員研究了1807例受感染的病例和5511例正常人對(duì)照。結(jié)果顯示,，該類突變中的的一個(gè)叫做rs6983267的突變體和結(jié)腸直腸癌的發(fā)生有顯著的關(guān)聯(lián)性。研究結(jié)果還發(fā)現(xiàn),，該類突變中不同突變體引發(fā)兩種癌癥的風(fēng)險(xiǎn)分配也有顯著差異,。
這一研究結(jié)果證實(shí)了人類染色體8q24的突變體對(duì)癌癥的發(fā)生具有明顯的效應(yīng)，并且該效應(yīng)依賴于組織類型的不同而有差異,。
Figure 1 - Fine mapping in the region 128.47–128.54 Mb of 8q24.
We present data for 82 SNPs that we genotyped in 1,088 individuals with CRC and 1,823 controls. These SNPs capture 92% of SNPs of >5% minor allele frequency at r2>0.8 in HapMap populations (Supplementary Fig. 2). (a) The most strongly associated SNP is rs10808556 (red), P = 2.2 10-6, which is substantially more associated than rs6983267 (green), the SNP that initially led us to the region (P = 2.4 10-4). (b) Controlling for rs10808556 in a logistic regression analysis, no SNP is significant at P < 0.05 after correcting for 82 hypotheses tested (threshold shown by a light gray line).
原文出處：
Nature Genetics August 2007, Volume 39 No 8
A common genetic risk factor for colorectal and prostate cancer - pp954 - 956
Christopher A Haiman, Loïc Le Marchand, Jennifer Yamamato, Daniel O Stram, Xin Sheng, Laurence N Kolonel, Anna H Wu, David Reich & Brian E Henderson
doi:10.1038/ng2098
Abstract | Full Text | PDF (140 KB) | Supplementary information
Haiman , Christopher
